Beneficial Effects of Minocycline on Cuprizone Induced Cortical Demyelination

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2010 Jun 15

PMID 20544279

Citations 29

Authors

Thomas Skripuletz

Elvira Miller

Darius Moharregh-Khiabani

Alexander Blank

Refik Pul

Viktoria Gudi

Corinna Trebst

Martin Stangel

Affiliations

Soon will be listed here.

Abstract

In this study, we investigated the potential of minocycline to influence cuprizone induced demyelination in the grey and white matter. To induce demyelination C57BL/6 mice were fed with cuprizone for up to 6 weeks and were analysed at different timepoints (week 0, 4, 5, 6). Mice treated with minocycline had less demyelination of the cortex and corpus callosum compared with sham treated animals. In the cortex decreased numbers of activated and proliferating microglia were found after 6 weeks of cuprizone feeding, while there were no significant effects for microglial infiltration of the corpus callosum. In addition to the beneficial effects on demyelination, minocycline prevented from motor coordination disturbance as shown in the beam walking test. For astrogliosis and the numbers of OPC and oligodendrocytes no treatment effects were found. In summary, minocycline treatment diminished the course of demyelination in the grey and white matter and prevented disturbances in motor coordination.

Citing Articles

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Endogenous Sox8 is a critical factor for timely remyelination and oligodendroglial cell repletion in the cuprizone model.

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Inhibiting microglia exacerbates the early effects of cuprizone in males in a rat model of multiple sclerosis, with no effect in females.

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Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm.

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