The Influence of Tetracyclines on T Cell Activation

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1995 Dec 1

PMID 8536384

Citations 31

Authors

M Kloppenburg

C L Verweij

A M Miltenburg

A J Verhoeven

M R Daha

B A Dijkmans

F C Breedveld

Affiliations

Soon will be listed here.

Abstract

Minocycline has been shown to have an anti-inflammatory effect in patients with rheumatoid arthritis (RA). Since there is evidence that RA is a T cell-mediated disease, we investigated the effect of minocycline on human T cell clones derived from the synovium of an RA patient. The T cells, when activated via the T cell receptor (TCR)/CD3 complex, were suppressed functionally by minocycline, resulting in a dose-dependent inhibition of T cell proliferation and reduction in production of IL-2, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha). Besides an inhibition of IL-2 production, minocycline exerted its effect on T cell proliferation by induction of a decreased IL-2 responsiveness. We showed that the chelating capacity of minocycline plays a crucial role in the inhibitory effect on T cell function, since the inhibitory effect on T cell proliferation could be annulled by addition of exogenous Ca2+. However, minocycline did not markedly influence the typical TCR/CD3-induced intracellular Ca2+ mobilization. Taken together, the results clearly indicate that minocycline has immunomodulating effects on human T cells.

Citing Articles

Tetracyclines in Rheumatoid Arthritis: Dual Anti-Inflammatory and Immunomodulatory Roles, Effectiveness, and Safety Insights.

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Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway.

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Host inflammatory response is the major factor in the progression of pneumonia.

Zhang Z, Wang P, Ma C, Wang J, Li W, Quan C Front Immunol. 2022; 13:929213.

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Revisiting Minocycline in Intracerebral Hemorrhage: Mechanisms and Clinical Translation.

Zhang R, Yong V, Xue M Front Immunol. 2022; 13:844163.

PMID: 35401553 PMC: 8993500. DOI: 10.3389/fimmu.2022.844163.

Tetracyclines Diminish IFN-γ and IL-17-Producing Adaptive and Innate Immune Cells in Multiple Sclerosis.

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PMID: 34899697 PMC: 8662812. DOI: 10.3389/fimmu.2021.739186.

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