Sodium Channel Na V 1.7 Immunoreactivity in Painful Human Dental Pulp and Burning Mouth Syndrome

Overview

Journal BMC Neurosci

Publisher Biomed Central

Specialty Neurology

Date 2010 Jun 10

PMID 20529324

Citations 14

Authors

Kiran Beneng

Tara Renton

Zehra Yilmaz

Yiangos Yiangou

Praveen Anand

Affiliations

Soon will be listed here.

Abstract

Background: Voltage gated sodium channels Na v 1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders.

Aims And Objectives: To study Na v 1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS), considered a neuropathic orofacial pain disorder.

Methods: Two groups of patients were recruited for this study. One group consisted of patients with dental pulpitis pain (n = 5) and controls (n = 12), and the other patients with BMS (n = 7) and controls (n = 10). BMS patients were diagnosed according to the International Association for the Study of Pain criteria; a pain history was collected, including the visual analogue scale (VAS). Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Na v 1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group.

Results: There was a significantly increased visual intensity score for Na v 1.7 in nerve fibres in the painful dental pulp specimens, compared to controls. Image analysis showed a trend for an increase of the Na v 1.7 immunoreactive % area in the painful pulp group, but this was not statistically significant. When expressed as a ratio of the neurofilament % area, there was a strong trend for an increase of Na v 1.7 in the painful pulp group. Na v 1.7 immunoreactive fibres were seen in abundance in the sub-mucosal layer of tongue biopsies, with no significant difference between BMS and controls.

Conclusion: Na v 1.7 sodium channel may play a significant role in inflammatory dental pain. Clinical trials with selective Na v 1.7 channel blockers should prioritize dental pulp pain rather than BMS.

Citing Articles

Small Fiber Neuropathy in Burning Mouth Syndrome: A Systematic Review.

Kouri M, Adamo D, Vardas E, Georgaki M, Canfora F, Mignogna M Int J Mol Sci. 2024; 25(21).

PMID: 39518993 PMC: 11546372. DOI: 10.3390/ijms252111442.

Determination of the Ideal Tooth Surface and Pain Threshold to Improve the Efficacy of an Electric Pulp Tester in the Diagnosis of Pulp Sensitivity and Vitality in Premolar and Molar Teeth: A Cross-Sectional Study.

Imtiaz T, Gurunathan D, Saikiran K Cureus. 2024; 15(12):e50754.

PMID: 38239553 PMC: 10794787. DOI: 10.7759/cureus.50754.

Terpenes in Inhibit Capsaicin Responses in Rat DRG Neurons via Na/K ATPase Activation.

Anand U, Anand P, Sodergren M Int J Mol Sci. 2023; 24(22).

PMID: 38003528 PMC: 10671062. DOI: 10.3390/ijms242216340.

Immunohistochemistry as a detection tool for ion channels involved in dental pain signaling.

Ramli R, Nafi S, Ahmad Tarmidzi N, Hasbullah N, Ghani N Saudi Dent J. 2022; 34(3):155-166.

PMID: 35935722 PMC: 9346947. DOI: 10.1016/j.sdentj.2022.02.004.

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain.

Kwon M, Jung I, Cha M, Lee B Front Pharmacol. 2021; 12:759730.

PMID: 34955831 PMC: 8694709. DOI: 10.3389/fphar.2021.759730.

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