Sodium Channel Nav1.8 Immunoreactivity in Painful Human Dental Pulp

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2005 Jul 9

PMID 16001984

Citations 14

Authors

T Renton

Y Yiangou

C Plumpton

S Tate

C Bountra

P Anand

Affiliations

Soon will be listed here.

Abstract

Background: The tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states.

Methods: Using specific antibodies for immunohistochemistry, we studied Nav1.8 immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain).

Results: Fibres immunoreactive for Nav1.8, were significantly increased on image analysis in the painful group: median (range) Nav1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006-0.24), painful 0.265 (0.13-0.5), P = 0.0019.

Conclusion: Nav1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states.

Citing Articles

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