BMPs in Periprosthetic Tissues Around Aseptically Loosened Total Hip Implants

Overview

Journal Acta Orthop

Specialty Orthopedics

Date 2010 Jun 3

PMID 20515435

Citations 2

Authors

Ville Waris

Eero Waris

Tarvo Sillat

Yrjo T Konttinen

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Primary and dynamically maintained periprosthetic bone formation is essential for osseointegration of hip implants to host bone. Bone morphogenetic proteins (BMPs) play a role in osteoinductive bone formation. We hypothesized that there is an increased local synthesis of BMPs in the synovial membrane-like interface around aseptically loosened total hip replacement (THR) implants, as body attempts to generate or maintain implant fixation.

Patients And Methods: We compared synovial membrane-like interface tissue from revised total hip replacements (rTHR, n = 9) to osteoarthritic control synovial membrane samples (OA, n = 11. Avidin-biotin-peroxidase complex staining and grading of BMP-2, BMP-4, BMP-6, and BMP-7 was done. Immunofluorescence staining was used to study BMP proteins produced by mesenchymal stromal/stem cells (MSCs) and osteoblasts.

Results And Interpretation: All BMPs studied were present in the synovial lining or lining-like layer, fibroblast-like stromal cells, interstitial macrophage-like cells, and endothelial cells. In OA and rTHR samples, BMP-6 positivity in cells, inducible by the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta, predominated over expression of other BMPs. Macrophage-like cells positive for BMP-4, inducible in macrophages by stimulation with particles, were more frequent around loosened implants than in control OA samples, but apparently not enough to prevent loosening. MSCs contained BMP-2, BMP-4, BMP-6, and BMP-7, but this staining diminished during osteogenesis, suggesting that BMPs are produced by progenitor cells in particular, probably for storage in the bone matrix.

Citing Articles

Gene Polymorphisms (, , , ) in Total Hip Arthroplasty Outcome Patients.

Rozmus D, Fiedorowicz E, Grzybowski R, Plominski J, Cieslinska A Int J Mol Sci. 2024; 25(15).

PMID: 39125794 PMC: 11311579. DOI: 10.3390/ijms25158225.

Peri-prosthetic tissue cells show osteogenic capacity to differentiate into the osteoblastic lineage.

Schoeman M, Oostlander A, Rooij K, Valstar E, Nelissen R J Orthop Res. 2016; 35(8):1732-1742.

PMID: 27714894 PMC: 5573935. DOI: 10.1002/jor.23457.

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