Colchicine-loaded Lipid Bilayer-coated 50 Nm Mesoporous Nanoparticles Efficiently Induce Microtubule Depolymerization Upon Cell Uptake

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2010 Jun 3

PMID 20515041

Citations 37

Authors

Valentina Cauda

Hanna Engelke

Anna Sauer

Delphine Arcizet

Christoph Brauchle

Joachim Radler

Thomas Bein

Affiliations

Soon will be listed here.

Abstract

We report on a one-step assembly route where supported lipid bilayers (SLB) are deposited on functionalized colloidal mesoporous silica (CMS) nanoparticles, resulting in a core-shell hybrid system (SLB@CMS). The supported membrane acts as an intact barrier against the escape of encapsulated dye molecules. These stable SLB@CMS particles loaded with the anticancer drug colchicine are readily taken up by cells and lead to the depolymerization of microtubules with remarkably enhanced efficiency as compared to the same dose of drug in solution.

Citing Articles

Anti-CD38 targeted nanotrojan horses stimulated by acoustic waves as therapeutic nanotools selectively against Burkitt's lymphoma cells.

Vighetto V, Conte M, Rosso G, Carofiglio M, Sidoti Abate F, Racca L Discov Nano. 2024; 19(1):28.

PMID: 38353903 PMC: 10866835. DOI: 10.1186/s11671-024-03976-z.

One-pot, degradable, silica nanocarriers with encapsulated oligonucleotides for mitochondrial specific targeting.

Trayford C, Wilhalm A, Habibovic P, Smeets H, van Tienen F, van Rijt S Discov Nano. 2023; 18(1):161.

PMID: 38127184 PMC: 10739632. DOI: 10.1186/s11671-023-03926-1.

Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD.

Hicks M, Liu X, Young C, Saleh K, Ji Y, Jiang J J Nanobiotechnology. 2023; 21(1):303.

PMID: 37641124 PMC: 10463982. DOI: 10.1186/s12951-023-01994-0.

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy.

Percivalle N, Carofiglio M, Conte M, Rosso G, Bentivogli A, Mesiano G Int J Mol Sci. 2022; 23(24).

PMID: 36555455 PMC: 9779745. DOI: 10.3390/ijms232415815.

The emergence of nanoporous materials in lung cancer therapy.

Radhakrishnan D, Mohanan S, Choi G, Choy J, Tiburcius S, Trinh H Sci Technol Adv Mater. 2022; 23(1):225-274.

PMID: 35875329 PMC: 9307116. DOI: 10.1080/14686996.2022.2052181.