Human Cord Blood Stem Cell Therapy for Treatment of Stress Urinary Incontinence

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2010 Jun 2

PMID 20514298

Citations 23

Authors

Chung No Lee

Jin Beum Jang

Ji Young Kim

Chester Koh

Jin Young Baek

Kyoung Jin Lee

Affiliations

Soon will be listed here.

Abstract

Our objective in this study was to evaluate the safety and efficacy of transurethral cord blood stem cell injection for treatment of stress urinary incontinence in women. Between July 2005 and July 2006, 39 women underwent transurethral umbilical cord blood stem cell injection performed by one operator at a single hospital. All patients had stress urinary incontinence. The patients were evaluated 1, 3, and 12 months postoperatively. No postoperative complications were observed. 28 patients (77.8%) were more than 50% satisfied according to the Patient's Satisfaction results after 1 month, 29 patients (83%) were more than 50% satisfied according to the Patient's Satisfaction results after 3 months, and 26 (72.2%) continuously showed more than 50% improvement after 12 months. Intrinsic sphincter deficiency and mixed stress incontinency improved in the ten patients evaluated by urodynamic study. Our results suggest that transurethral umbilical cord blood stem cell injection is an effective treatment for women with all types of stress urinary incontinence.

Citing Articles

Exploring the role of laser therapy for stress urinary incontinence: a literature review.

Li P, Ding D Lasers Med Sci. 2025; 40(1):125.

PMID: 40038121 DOI: 10.1007/s10103-025-04385-z.

Cell Therapy in the Treatment of Female Stress Urinary Incontinence: Current Status and Future Proposals.

Gonzalez Enguita C, Garranzo Garcia-Ibarrola M, Tufet I Jaumont J, Garde Garcia H, Gonzalez Lopez R, Quintana Franco L Life (Basel). 2024; 14(7).

PMID: 39063615 PMC: 11278173. DOI: 10.3390/life14070861.

Regenerative Medicine in Urogynecology: Where We Are and Where We Want to Be.

Henderson T, Christman K, Alperin M Urogynecology (Phila). 2024; 30(5):519-527.

PMID: 38683203 PMC: 11342648. DOI: 10.1097/SPV.0000000000001461.

Body fluid-derived stem cells - an untapped stem cell source in genitourinary regeneration.

Huang R, Li Q, Ma J, Atala A, Zhang Y Nat Rev Urol. 2023; 20(12):739-761.

PMID: 37414959 PMC: 11639537. DOI: 10.1038/s41585-023-00787-2.

Stem-cell therapy in stress urinary incontinence: A review.

Li P, Ding D Tzu Chi Med J. 2023; 35(2):111-119.

PMID: 37261308 PMC: 10227685. DOI: 10.4103/tcmj.tcmj_145_22.

References

Vendrame M, Cassady J, Newcomb J, Butler T, Pennypacker K, Zigova T . Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke. 2004; 35(10):2390-5. DOI: 10.1161/01.STR.0000141681.06735.9b. View

Jejurikar S, Kuzon Jr W . Satellite cell depletion in degenerative skeletal muscle. Apoptosis. 2003; 8(6):573-8. DOI: 10.1023/A:1026127307457. View

Dasari V, Spomar D, Li L, Gujrati M, Rao J, Dinh D . Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Neurochem Res. 2007; 33(1):134-49. PMC: 2167626. DOI: 10.1007/s11064-007-9426-6. View

Strasser H, Marksteiner R, Margreiter E, Pinggera G, Mitterberger M, Fritsch H . [Stem cell therapy for urinary incontinence]. Urologe A. 2004; 43(10):1237-41. DOI: 10.1007/s00120-004-0700-9. View

Renault V, Thornell L, Eriksson P, Butler-Browne G, Mouly V, Thorne L . Regenerative potential of human skeletal muscle during aging. Aging Cell. 2003; 1(2):132-9. DOI: 10.1046/j.1474-9728.2002.00017.x. View

Thornell L, Lindstrom M, Renault V, Mouly V, Butler-Browne G . Satellite cells and training in the elderly. Scand J Med Sci Sports. 2003; 13(1):48-55. DOI: 10.1034/j.1600-0838.2003.20285.x. View

Gluckman E, Broxmeyer H, Auerbach A, Friedman H, Douglas G, Devergie A . Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med. 1989; 321(17):1174-8. DOI: 10.1056/NEJM198910263211707. View

Hannestad Y, Rortveit G, Sandvik H, Hunskaar S . A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of Incontinence in the County of Nord-Trøndelag. J Clin Epidemiol. 2000; 53(11):1150-7. DOI: 10.1016/s0895-4356(00)00232-8. View

Fulle S, Protasi F, Di Tano G, Pietrangelo T, Beltramin A, Boncompagni S . The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp Gerontol. 2004; 39(1):17-24. DOI: 10.1016/j.exger.2003.09.012. View

10.

Yiou R, Lefaucheur J, Atala A . The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells. Anat Embryol (Berl). 2003; 206(6):429-35. DOI: 10.1007/s00429-003-0313-x. View

11.

Norton P, Brubaker L . Urinary incontinence in women. Lancet. 2006; 367(9504):57-67. DOI: 10.1016/S0140-6736(06)67925-7. View

12.

Cannon T, Lee J, Somogyi G, Pruchnic R, Smith C, Huard J . Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra. Urology. 2003; 62(5):958-63. DOI: 10.1016/s0090-4295(03)00679-4. View

13.

Yokoyama T, Yoshimura N, Dhir R, Qu Z, Fraser M, Kumon H . Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence. J Urol. 2000; 165(1):271-6. DOI: 10.1097/00005392-200101000-00077. View