Genome Factor and Gene Pleiotropy Hypotheses in Protein Evolution

Overview

Journal Biol Direct

Publisher Biomed Central

Specialty Biology

Date 2010 May 26

PMID 20497565

Citations 9

Authors

Yanwu Zeng

Xun Gu

Affiliations

Soon will be listed here.

Abstract

The debate of genomic correlations between sequence conservation, protein connectivity, gene essentiality and gene expression, has generated a number of new hypotheses that are challenging the classical framework of molecular evolution. For instance, the translational selection hypothesis claims that the determination of the rate of protein evolution is the protein stability to avoid the misfolding toxicity. In this short article, we propose that gene pleiotropy, the capacity for affecting multiple phenotypes, may play a vital role in molecular evolution. We discuss several approaches to testing this hypothesis.

Citing Articles

d/d-H, a New Test to Distinguish Different Selection Modes in Protein Evolution and Cancer Evolution.

Gu X J Mol Evol. 2022; 90(5):342-351.

PMID: 35920867 DOI: 10.1007/s00239-022-10064-2.

A Simple Evolutionary Model of Genetic Robustness After Gene Duplication.

Gu X J Mol Evol. 2022; 90(5):352-361.

PMID: 35913597 DOI: 10.1007/s00239-022-10065-1.

Genepleio software for effective estimation of gene pleiotropy from protein sequences.

Chen W, Chen D, Zhao M, Zou Y, Zeng Y, Gu X Biomed Res Int. 2015; 2015:269150.

PMID: 25629041 PMC: 4299487. DOI: 10.1155/2015/269150.

Pleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.

Gu X Genetics. 2014; 197(4):1357-63.

PMID: 24899162 PMC: 4125405. DOI: 10.1534/genetics.114.164673.

Enzyme recruitment and its role in metabolic expansion.

Schulenburg C, Miller B Biochemistry. 2014; 53(5):836-45.

PMID: 24483367 PMC: 3985712. DOI: 10.1021/bi401667f.

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