Targeting Antioxidant and Antithrombotic Biotherapeutics to Endothelium

Overview

Journal Semin Thromb Hemost

Publisher Thieme

Specialties Cardiology & Vascular Diseases
Hematology

Date 2010 May 22

PMID 20490983

Citations 11

Authors

Ronald Carnemolla

Vladimir V Shuvaev

Vladimir R Muzykantov

Affiliations

Soon will be listed here.

Abstract

The endothelium is one of the key targets for pharmacological interventions in oxidative stress and thrombosis, two conditions that are notoriously difficult to treat due to limited efficacy and precision of action of current drugs. Design of molecular and nano-devices that deliver potent antioxidant and antithrombotic therapeutic enzymes to the endothelium holds promise to improve the potency, localization, timing, specificity, safety, and mechanistic precision of these interventions. In particular, cell adhesion molecules expressed on the surface of resting and pathologically altered endothelial cells can be used for drug delivery to the endothelial surface (preferable for thrombolytics) and into intracellular compartments (preferable for antioxidants). Drug delivery platforms including protein conjugates, recombinant fusion constructs, and stealth polymer carriers designed to target these drugs to endothelium are reviewed in this article.

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Targeting therapeutics to endothelium: are we there yet?.

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Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect.

Greineder C, Brenza J, Carnemolla R, Zaitsev S, Hood E, Pan D FASEB J. 2015; 29(8):3483-92.

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Icam-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation.

Ferrer M, Shuvaev V, Zern B, Composto R, Muzykantov V, Eckmann D PLoS One. 2014; 9(7):e102329.

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Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation.

Hood E, Chorny M, Greineder C, Alferiev I, Levy R, Muzykantov V Biomaterials. 2014; 35(11):3708-15.

PMID: 24480537 PMC: 4343528. DOI: 10.1016/j.biomaterials.2014.01.023.

References

Kelly K, Allport J, Tsourkas A, Shinde-Patil V, Josephson L, Weissleder R . Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res. 2005; 96(3):327-36. DOI: 10.1161/01.RES.0000155722.17881.dd. View

Straley K, Green S . Rapid transport of internalized P-selectin to late endosomes and the TGN: roles in regulating cell surface expression and recycling to secretory granules. J Cell Biol. 2000; 151(1):107-16. PMC: 2189813. DOI: 10.1083/jcb.151.1.107. View

Lindner J, Song J, Christiansen J, Klibanov A, Xu F, Ley K . Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001; 104(17):2107-12. DOI: 10.1161/hc4201.097061. View

Blasi F, Carmeliet P . uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol. 2002; 3(12):932-43. DOI: 10.1038/nrm977. View

Danilov S, Atochina E, Hiemisch H, Moldobayeva A, Sakharov I, Deichman G . Interaction of mAb to angiotensin-converting enzyme (ACE) with antigen in vitro and in vivo: antibody targeting to the lung induces ACE antigenic modulation. Int Immunol. 1994; 6(8):1153-60. DOI: 10.1093/intimm/6.8.1153. View

Scherpereel A, Rome J, Wiewrodt R, Watkins S, Harshaw D, Alder S . Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature. J Pharmacol Exp Ther. 2002; 300(3):777-86. DOI: 10.1124/jpet.300.3.777. View

Ding B, Hong N, Christofidou-Solomidou M, Gottstein C, Albelda S, Cines D . Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med. 2009; 180(3):247-56. PMC: 2724717. DOI: 10.1164/rccm.200809-1433OC. View

Koo D, Welsh K, West N, Channon K, Penington A, Roake J . Endothelial cell protection against ischemia/reperfusion injury by lecithinized superoxide dismutase. Kidney Int. 2001; 60(2):786-96. DOI: 10.1046/j.1523-1755.2001.060002786.x. View

Spragg D, Alford D, Greferath R, LARSEN C, Lee K, Gurtner G . Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc Natl Acad Sci U S A. 1997; 94(16):8795-800. PMC: 23135. DOI: 10.1073/pnas.94.16.8795. View

10.

Idell S . Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med. 2003; 31(4 Suppl):S213-20. DOI: 10.1097/01.CCM.0000057846.21303.AB. View

11.

Beckman J, Minor Jr R, White C, Repine J, Rosen G, Freeman B . Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem. 1988; 263(14):6884-92. View

12.

Von Asmuth E, Smeets E, Ginsel L, Onderwater J, Leeuwenberg J, Buurman W . Evidence for endocytosis of E-selectin in human endothelial cells. Eur J Immunol. 1992; 22(10):2519-26. DOI: 10.1002/eji.1830221009. View

13.

Liu J, Gurewich V . Fragment E-2 from fibrin substantially enhances pro-urokinase-induced Glu-plasminogen activation. A kinetic study using the plasmin-resistant mutant pro-urokinase Ala-158-rpro-UK. Biochemistry. 1992; 31(27):6311-7. DOI: 10.1021/bi00142a021. View

14.

Runge M, Quertermous T, Zavodny P, Love T, Bode C, Freitag M . A recombinant chimeric plasminogen activator with high affinity for fibrin has increased thrombolytic potency in vitro and in vivo. Proc Natl Acad Sci U S A. 1991; 88(22):10337-41. PMC: 52923. DOI: 10.1073/pnas.88.22.10337. View

15.

Villanueva F, Jankowski R, Klibanov S, Pina M, Alber S, Watkins S . Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation. 1998; 98(1):1-5. DOI: 10.1161/01.cir.98.1.1. View

16.

Atochina E, Hiemisch H, Muzykantov V, Danilov S . Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme. Lung. 1992; 170(6):349-58. DOI: 10.1007/BF00177581. View

17.

Nishikawa M, Hashida M, Takakura Y . Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis. Adv Drug Deliv Rev. 2009; 61(4):319-26. DOI: 10.1016/j.addr.2009.01.001. View

18.

Christofidou-Solomidou M, Pietra G, Solomides C, Arguiris E, Harshaw D, FitzGerald G . Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs. Am J Physiol Lung Cell Mol Physiol. 2000; 278(4):L794-805. DOI: 10.1152/ajplung.2000.278.4.L794. View

19.

Kok R, Everts M, Asgeirsdottir S, Meijer D, Molema G . Cellular handling of a dexamethasone-anti-E-selectin immunoconjugate by activated endothelial cells: comparison with free dexamethasone. Pharm Res. 2002; 19(11):1730-5. DOI: 10.1023/a:1020769716288. View

20.

Freeman B, Young S, Crapo J . Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem. 1983; 258(20):12534-42. View