UPAR: a Versatile Signalling Orchestrator

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2002 Dec 4

PMID 12461559

Citations 461

Authors

Francesco Blasi

Peter Carmeliet

Affiliations

Soon will be listed here.

Abstract

The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

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