B Cell Development in GALT: Role of Bacterial Superantigen-like Molecules

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2010 May 21

PMID 20483765

Citations 19

Authors

Kari M Severson

Michael Mallozzi

Adam Driks

Katherine L Knight

Affiliations

Soon will be listed here.

Abstract

Intestinal bacteria drive the formation of lymphoid tissues, and in rabbit, bacteria also promote development of the preimmune Ab repertoire and positive selection of B cells in GALT. Previous studies indicated that Bacillus subtilis promotes B cell follicle formation in GALT, and we investigated the mechanism by which B. subtilis stimulates B cells. We found that spores of B. subtilis and other Bacillus species, including Bacillus anthracis, bound rabbit IgM through an unconventional, superantigen-like binding site, and in vivo, surface molecules of B. anthracis spores promoted GALT development. Our study provides direct evidence that B cell development in GALT may be driven by superantigen-like molecules, and furthermore, that bacterial spores modulate host immunity.

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