Evasion of Innate and Adaptive Immune Responses by Influenza A Virus

Overview

Journal Cell Microbiol

Publisher Wiley

Specialties Cell Biology
Microbiology

Date 2010 May 21

PMID 20482552

Citations 53

Authors

Mirco Schmolke

Adolfo Garcia-Sastre

Affiliations

Soon will be listed here.

Abstract

Host organisms have developed sophisticated antiviral responses in order to defeat emerging influenza A viruses (IAVs). At the same time IAVs have evolved immune evasion strategies. The immune system of mammals provides several lines of defence to neutralize invading pathogens or limit their replication. Here, we summarize the mammalian innate and adaptive immune mechanisms involved in host defence against viral infection and review strategies by which IAVs avoid, circumvent or subvert these mechanisms. We highlight well-characterized, as well as recently described features of this intriguing virus-host molecular battle.

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References

GERHARD W . The role of the antibody response in influenza virus infection. Curr Top Microbiol Immunol. 2001; 260:171-90. DOI: 10.1007/978-3-662-05783-4_9. View

Akira S, Takeda K, Kaisho T . Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001; 2(8):675-80. DOI: 10.1038/90609. View

Le Goffic R, Balloy V, Lagranderie M, Alexopoulou L, Escriou N, Flavell R . Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog. 2006; 2(6):e53. PMC: 1475659. DOI: 10.1371/journal.ppat.0020053. View

Bender B, Croghan T, Zhang L, Small Jr P . Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med. 1992; 175(4):1143-5. PMC: 2119177. DOI: 10.1084/jem.175.4.1143. View

Gack M, Albrecht R, Urano T, Inn K, Huang I, Carnero E . Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe. 2009; 5(5):439-49. PMC: 2737813. DOI: 10.1016/j.chom.2009.04.006. View

Herold S, von Wulffen W, Steinmueller M, Pleschka S, Kuziel W, Mack M . Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol. 2006; 177(3):1817-24. DOI: 10.4049/jimmunol.177.3.1817. View

Shen J, Ma J, Wang Q . Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. PLoS One. 2009; 4(11):e7789. PMC: 2773012. DOI: 10.1371/journal.pone.0007789. View

Vigerust D, Shepherd V . Virus glycosylation: role in virulence and immune interactions. Trends Microbiol. 2007; 15(5):211-8. PMC: 7127133. DOI: 10.1016/j.tim.2007.03.003. View

Kedzierska K, Venturi V, Field K, Davenport M, Turner S, Doherty P . Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells. Proc Natl Acad Sci U S A. 2006; 103(24):9184-9. PMC: 1482587. DOI: 10.1073/pnas.0603289103. View

10.

Moltedo B, Lopez C, Pazos M, Becker M, Hermesh T, Moran T . Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. J Immunol. 2009; 183(6):3569-73. DOI: 10.4049/jimmunol.0900091. View

11.

Le Goffic R, Pothlichet J, Vitour D, Fujita T, Meurs E, Chignard M . Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol. 2007; 178(6):3368-72. DOI: 10.4049/jimmunol.178.6.3368. View

12.

Schmitz N, Kurrer M, Bachmann M, Kopf M . Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol. 2005; 79(10):6441-8. PMC: 1091664. DOI: 10.1128/JVI.79.10.6441-6448.2005. View

13.

Nemeroff M, Barabino S, Li Y, Keller W, KRUG R . Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell. 1998; 1(7):991-1000. DOI: 10.1016/s1097-2765(00)80099-4. View

14.

Hidaka F, Matsuo S, Muta T, Takeshige K, Mizukami T, Nunoi H . A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy. Clin Immunol. 2006; 119(2):188-94. DOI: 10.1016/j.clim.2006.01.005. View

15.

Parvin J, Moscona A, Pan W, Leider J, Palese P . Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1. J Virol. 1986; 59(2):377-83. PMC: 253087. DOI: 10.1128/JVI.59.2.377-383.1986. View

16.

Kawai T, Akira S . Antiviral signaling through pattern recognition receptors. J Biochem. 2006; 141(2):137-45. DOI: 10.1093/jb/mvm032. View

17.

Barchet W, Krug A, Cella M, Newby C, Fischer J, Dzionek A . Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Eur J Immunol. 2004; 35(1):236-42. DOI: 10.1002/eji.200425583. View

18.

Mogensen T . Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009; 22(2):240-73, Table of Contents. PMC: 2668232. DOI: 10.1128/CMR.00046-08. View

19.

Rimmelzwaan G, Kreijtz J, Bodewes R, Fouchier R, Osterhaus A . Influenza virus CTL epitopes, remarkably conserved and remarkably variable. Vaccine. 2009; 27(45):6363-5. DOI: 10.1016/j.vaccine.2009.01.016. View

20.

Kozak W, Zheng H, Conn C, Soszynski D, Van der Ploeg L, Kluger M . Thermal and behavioral effects of lipopolysaccharide and influenza in interleukin-1 beta-deficient mice. Am J Physiol. 1995; 269(5 Pt 2):R969-77. DOI: 10.1152/ajpregu.1995.269.5.R969. View