Non-long Terminal Repeat (non-LTR) Retrotransposons: Mechanisms, Recent Developments, and Unanswered Questions

Overview

Journal Mob DNA

Publisher Biomed Central

Specialty Genetics

Date 2010 May 14

PMID 20462415

Citations 51

Authors

Jeffrey S Han

Affiliations

Soon will be listed here.

Abstract

Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed.

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