Non-canonical Activation of Notch Signaling/target Genes in Vertebrates

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2010 May 12

PMID 20458516

Citations 46

Authors

Rajendran Sanalkumar

Sivadasan Bindu Dhanesh

Jackson James

Affiliations

Soon will be listed here.

Abstract

Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis. Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch signaling and target gene activation in vertebrates with specific emphasis on their functional relevance.

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