Peritoneal Adipocytes and Their Role in Inflammation During Peritoneal Dialysis

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2010 May 11

PMID 20454534

Citations 8

Authors

Kar Neng Lai

Joseph C K Leung

Affiliations

Soon will be listed here.

Abstract

Adipose tissue is a major site of chronic inflammation associated with peritoneal dialysis (PD) frequently complicating peritonitis. Adiposity-associated inflammation plays a significant contributory role in the development of chronic inflammation in patients undergoing maintenance PD. However, the molecular and cellular mechanisms of this link remain uncertain. Adipose tissue synthesizes different adipokines and cytokines that orchestrate and regulate inflammation, insulin action, and glucose metabolism locally and systemically. In return, inflammation retards adipocyte differentiation and further exacerbates adipose dysfunction and inflammation. An understanding of the inflammatory roles played by adipose tissue during PD and the healing mechanism of injured mesothelium will help to devise new therapeutic approach to slow the progression of peritoneal damage during peritoneal dialysis. This article reviews the roles of peritoneal adipose tissue in chronic peritoneal inflammation under PD and in serosal repair during PD.

Citing Articles

Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma.

Su H, Zou R, Su J, Chen X, Yang H, An N Front Immunol. 2024; 15:1387292.

PMID: 38779674 PMC: 11109381. DOI: 10.3389/fimmu.2024.1387292.

Intercellular communication in peritoneal dialysis.

Sheng L, Shan Y, Dai H, Yu M, Sun J, Huang L Front Physiol. 2024; 15:1331976.

PMID: 38390449 PMC: 10882094. DOI: 10.3389/fphys.2024.1331976.

Fasting influences aquaporin expression, water transport and adipocyte metabolism in the peritoneal membrane.

Costa I, Hautem N, Schiano G, Uchida S, Nishino T, Devuyst O Nephrol Dial Transplant. 2022; 38(6):1408-1420.

PMID: 36520078 PMC: 10229272. DOI: 10.1093/ndt/gfac318.

Regulatory Role of the Adipose Microenvironment on Ovarian Cancer Progression.

Chehade H, Tedja R, Ramos H, Bawa T, Adzibolosu N, Gogoi R Cancers (Basel). 2022; 14(9).

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Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer.

Guerra B, Issinger O Pharmaceuticals (Basel). 2020; 13(10).

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