Disorderly Conduct in Gammadelta Versus Alphabeta T Cell Lineage Commitment

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2010 May 11

PMID 20451409

Citations 9

Authors

Kavitha Narayan

Joonsoo Kang

Affiliations

Soon will be listed here.

Abstract

The mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.

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