The Use of Self-expanding Stents in Esophageal and Gastroesophageal Junction Cancer Palliation: a Meta-analysis and Meta-regression Analysis of Outcomes

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2010 May 5

PMID 20440646

Citations 17

Authors

George Sgourakis

Ines Gockel

Arnold Radtke

Georgia Dedemadi

Konstantinos Goumas

Sofia Mylona

Hauke Lang

Achilleas Tsiamis

Constantine Karaliotas

Affiliations

Soon will be listed here.

Abstract

Background: The objective of this study was to examine the impact of self-expanding stents versus locoregional treatment modalities in the setting of esophageal cancer palliation.

Methods: The present meta-analysis pooled the effects of outcomes of 1,027 patients enrolled in 16 randomized controlled trials.

Results: The meta-analysis revealed an advantage to the use of stents compared to locoregional modality treatments with respect to the number of patients requiring reinterventions, although the latter treatment arm had a higher 1-year survival. No difference was observed between the use of the antireflux stents and conventional stents in relieving reflux. Previous chemoradiotherapy had no impact on complications, procedural deaths, and overall patient survival. Differences in outcomes among stents were minimal.

Conclusions: Conventional self-expanding stents and anti-reflux stents are equally effective. Although the risk difference for 1-year survival favoured locoregional palliative treatment modalities, the latter were associated with a higher number of patients requiring reintervention.

Citing Articles

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