Trafficking of Immune Cells in the Central Nervous System

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2010 May 5

PMID 20440079

Citations 272

Authors

Emma H Wilson

Wolfgang Weninger

Christopher A Hunter

Affiliations

Soon will be listed here.

Abstract

The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomical sites (i.e., meninges, cerebrospinal fluid, and parenchyma) associated with the CNS can also be deleterious. Therefore, control of lymphocyte entry and migration within the brain is vital to regulate protective and pathological responses. In this review, several recent advances are highlighted that provide new insights into the processes that regulate leukocyte access to, and movement within, the brain.

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