Do Viruses Subvert Cholesterol Homeostasis to Induce Host Cubic Membranes?

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2010 May 4

PMID 20434915

Citations 33

Authors

Yuru Deng

Zakaria A Almsherqi

Mary M L Ng

Sepp D Kohlwein

Affiliations

Soon will be listed here.

Abstract

Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein-protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the 'virus factory' and offer new avenues to combat viral infections.

Citing Articles

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Zhang J, Zhu Y, Wang X, Wang J Front Immunol. 2023; 14:1268104.

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COVID-19 Biogenesis and Intracellular Transport.

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