Virus Factories: Associations of Cell Organelles for Viral Replication and Morphogenesis

Overview

Journal Biol Cell

Specialty Cell Biology

Date 2005 Jan 20

PMID 15656780

Citations 244

Authors

Reyes R Novoa

Gloria Calderita

Rocio Arranz

Juan Fontana

Harald Granzow

Cristina Risco

Affiliations

Soon will be listed here.

Abstract

Genome replication and assembly of viruses often takes place in specific intracellular compartments where viral components concentrate, thereby increasing the efficiency of the processes. For a number of viruses the formation of 'factories' has been described, which consist of perinuclear or cytoplasmic foci that mostly exclude host proteins and organelles but recruit specific cell organelles, building a unique structure. The formation of the viral factory involves a number of complex interactions and signalling events between viral and cell factors. Mitochondria, cytoplasmic membranes and cytoskeletal components frequently participate in the formation of viral factories, supplying basic and common needs for key steps in the viral replication cycle.

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