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Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake Between Mouse and Rat Hepatocytes

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 2010 Apr 28
PMID 20421393
Citations 3
Authors
Tomomi Furihata
Yukina Fukuchi
Minami Iikura
Misato Hashizume
Atsushi Miyajima
Miki Nagai
Kan Chiba
Affiliations
Soon will be listed here.
Abstract

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and no CNT2-dependent nucleoside uptake was observed, while rat hepatocytes exhibited high CNT2-dependent nucleoside uptake activity levels with abundant CNT2 mRNA expression. We concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.

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