Clozapine: a Distinct, Poorly Understood and Under-used Molecule

Overview

Journal J Psychiatry Neurosci

Specialty Psychiatry

Date 2010 Apr 28

PMID 20420765

Citations 23

Authors

Ridha Joober

Patricia Boksa

Affiliations

Soon will be listed here.

Citing Articles

Sex differences in schizophrenia-spectrum diagnoses: results from a 30-year health record registry.

Ferrara M, Curtarello E, Gentili E, Domenicano I, Vecchioni L, Zese R Arch Womens Ment Health. 2023; 27(1):11-20.

PMID: 37730924 PMC: 10791808. DOI: 10.1007/s00737-023-01371-8.

Dopamine Receptor Ligand Selectivity-An In Silico/In Vitro Insight.

Zell L, Bretl A, Temml V, Schuster D Biomedicines. 2023; 11(5).

PMID: 37239139 PMC: 10216180. DOI: 10.3390/biomedicines11051468.

Clozapine use at a specialised psychiatric hospital in Johannesburg.

Ord K, Marais B S Afr J Psychiatr. 2023; 29:1999.

PMID: 37151370 PMC: 10157415. DOI: 10.4102/sajpsychiatry.v29i0.1999.

What are the barriers and facilitators of clozapine use in early psychosis? A survey of UK early intervention clinicians.

Oloyede E, Blackman G, Mantell B, Harris E, Williams J, Taylor D Schizophrenia (Heidelb). 2023; 9(1):26.

PMID: 37117237 PMC: 10147630. DOI: 10.1038/s41537-023-00353-0.

Seventy Years of Antipsychotic Development: A Critical Review.

Shad M Biomedicines. 2023; 11(1).

PMID: 36672638 PMC: 9856208. DOI: 10.3390/biomedicines11010130.

References

Koen L, Magni P, Niehaus D, Le Roux A . Antipsychotic prescription patterns in Xhosa patients with schizophrenia or schizoaffective disorder. Afr J Psychiatry (Johannesbg). 2009; 11(4):287-90. View

Kumra S, Kranzler H, Gerbino-Rosen G, Kester H, De Thomas C, Kafantaris V . Clozapine and "high-dose" olanzapine in refractory early-onset schizophrenia: a 12-week randomized and double-blind comparison. Biol Psychiatry. 2007; 63(5):524-9. DOI: 10.1016/j.biopsych.2007.04.043. View

Kim D, Maneen M, Stahl S . Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia. Neurotherapeutics. 2008; 6(1):78-85. PMC: 5084257. DOI: 10.1016/j.nurt.2008.10.020. View

Nasrallah H . The roles of efficacy, safety, and tolerability in antipsychotic effectiveness: practical implications of the CATIE schizophrenia trial. J Clin Psychiatry. 2007; 68 Suppl 1:5-11. View

Wheeler A, Humberstone V, Robinson E, Sheridan J, Joyce P . Impact of audit and feedback on antipsychotic prescribing in schizophrenia. J Eval Clin Pract. 2009; 15(3):441-50. DOI: 10.1111/j.1365-2753.2008.01032.x. View

Hong C, Chen J, Chiu H, Sim C . A double-blind comparative study of clozapine versus chlorpromazine on Chinese patients with treatment-refractory schizophrenia. Int Clin Psychopharmacol. 1997; 12(3):123-30. DOI: 10.1097/00004850-199705000-00001. View

Meltzer H, Alphs L, Green A, Altamura A, Anand R, Bertoldi A . Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry. 2003; 60(1):82-91. DOI: 10.1001/archpsyc.60.1.82. View

Elkis H . Treatment-resistant schizophrenia. Psychiatr Clin North Am. 2007; 30(3):511-33. DOI: 10.1016/j.psc.2007.04.001. View

Ascher-Svanum H, Zhu B, Faries D, Lacro J, Dolder C, Peng X . Adherence and persistence to typical and atypical antipsychotics in the naturalistic treatment of patients with schizophrenia. Patient Prefer Adherence. 2009; 2:67-77. PMC: 2770396. DOI: 10.2147/ppa.s2940. View

10.

Saha S, Chant D, McGrath J . A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?. Arch Gen Psychiatry. 2007; 64(10):1123-31. DOI: 10.1001/archpsyc.64.10.1123. View

11.

Blouin M, Tremblay A, Jalbert M, Venables H, Bouchard R, Roy M . Adiposity and eating behaviors in patients under second generation antipsychotics. Obesity (Silver Spring). 2008; 16(8):1780-7. DOI: 10.1038/oby.2008.277. View

12.

Lieberman J, Stroup T, McEvoy J, Swartz M, Rosenheck R, Perkins D . Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 2005; 353(12):1209-23. DOI: 10.1056/NEJMoa051688. View

13.

Kane J, Marder S, Schooler N, Wirshing W, Umbricht D, Baker R . Clozapine and haloperidol in moderately refractory schizophrenia: a 6-month randomized and double-blind comparison. Arch Gen Psychiatry. 2001; 58(10):965-72. DOI: 10.1001/archpsyc.58.10.965. View

14.

Kapur S, Seeman P . Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis. Am J Psychiatry. 2001; 158(3):360-9. DOI: 10.1176/appi.ajp.158.3.360. View

15.

Tang Y, Mao P, Jiang F, Chen Q, Wang C, Cai Z . Clozapine in China. Pharmacopsychiatry. 2008; 41(1):1-9. DOI: 10.1055/s-2007-993224. View

16.

Novick D, Haro J, Perrin E, Suarez D, Texeira J . Tolerability of outpatient antipsychotic treatment: 36-month results from the European Schizophrenia Outpatient Health Outcomes (SOHO) study. Eur Neuropsychopharmacol. 2009; 19(8):542-50. DOI: 10.1016/j.euroneuro.2009.03.003. View

17.

Goodwin G, Fleischhacker W, Arango C, Baumann P, Davidson M, De Hert M . Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice. Eur Neuropsychopharmacol. 2009; 19(7):520-32. DOI: 10.1016/j.euroneuro.2009.04.003. View

18.

Hayhurst K, Brown P, Lewis S . The cost-effectiveness of clozapine: a controlled, population-based, mirror-image study. J Psychopharmacol. 2002; 16(2):169-75. DOI: 10.1177/026988110201600208. View

19.

Meltzer H, Li Z, Kaneda Y, Ichikawa J . Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(7):1159-72. DOI: 10.1016/j.pnpbp.2003.09.010. View

20.

Girgis R, Javitch J, Lieberman J . Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway. Mol Psychiatry. 2008; 13(10):918-29. PMC: 3618283. DOI: 10.1038/mp.2008.40. View