Chronic Sleep Deprivation Markedly Reduces Coagulation Factor VII Expression

Overview

Journal Haematologica

Specialty Hematology

Date 2010 Apr 27

PMID 20418241

Citations 3

Authors

Mirko Pinotti

Cristiano Bertolucci

Elena Frigato

Alessio Branchini

Nicola Cavallari

Kenkichi Baba

Susana Contreras-Alcantara

J Christopher Ehlen

Francesco Bernardi

Ketema N Paul

Gianluca Tosini

Affiliations

Soon will be listed here.

Abstract

Chronic sleep loss, a common feature of human life in industrialized countries, is associated to cardiovascular disorders. Variations in functional parameters of coagulation might contribute to explain this relationship. By exploiting the mouse model and a specifically designed protocol, we demonstrated that seven days of partial sleep deprivation significantly decreases (-30.5%) the thrombin generation potential in plasma evaluated upon extrinsic (TF/FVIIa pathway) but not intrinsic activation of coagulation. This variation was consistent with a decrease (-49.8%) in the plasma activity levels of factor VII (FVII), the crucial physiologicalal trigger of coagulation, which was even more pronounced at the liver mRNA level (-85.7%). The recovery in normal sleep conditions for three days completely restored thrombin generation and FVII activity in plasma. For the first time, we demonstrate that chronic sleep deprivation on its own reduces, in a reversible manner, the FVII expression levels, thus influencing the TF/FVIIa activation pathway efficiency.

Citing Articles

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