J Christopher Ehlen
Overview
Explore the profile of J Christopher Ehlen including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
756
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Recent Articles
1.
Ralston M, Ehlen J, Paul K
Front Neurosci
. 2024 Nov;
18:1478820.
PMID: 39544910
There are well-documented gender differences in the risk and severity of sleep disorders and associated comorbidities. While fundamental sex differences in sleep regulatory mechanisms may contribute to gender disparities, biological...
2.
Stowie A, Qiao Z, Buonfiglio D, Beckner D, Ehlen J, Benveniste M, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2209329120.
PMID: 36656857
The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of GABAergic neurons which form a neural network responsible for synchronizing most physiological and behavioral circadian rhythms in mammals. To...
3.
Bush B, Donnay C, Andrews E, Lewis-Sanders D, Gray C, Qiao Z, et al.
Elife
. 2022 Sep;
11.
PMID: 36149059
Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep...
4.
Mekbib T, Suen T, Rollins-Hairston A, Smith K, Armstrong A, Gray C, et al.
PLoS Genet
. 2022 Jul;
18(7):e1010305.
PMID: 35789210
Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator...
5.
Ray A, Canal C, Ehlen J, Rice K, Murnane K
Neurotoxicology
. 2019 Jun;
74:91-99.
PMID: 31163210
There are no Food and Drug Administration approved pharmacotherapies for methamphetamine (METH) overdose, thus identifying novel drug targets to prevent this devastating adverse event is a public-health imperative. Previous research...
6.
Nichols I, Jones M, Okere C, Ananaba G, Bush B, Gray C, et al.
PLoS One
. 2017 Nov;
12(11):e0187071.
PMID: 29125838
Nitrergic neurons of the dorsal raphe nucleus (DRN) may play a role in physiological stress responses. The caudal lateral wings (CLW) are unique compared to other rostral-caudal DRN sub-regions because...
7.
Ehlen J, Brager A, Baggs J, Pinckney L, Gray C, DeBruyne J, et al.
Elife
. 2017 Jul;
6.
PMID: 28726633
Sleep loss can severely impair the ability to perform, yet the ability to recover from sleep loss is not well understood. Sleep regulatory processes are assumed to lie exclusively within...
8.
Brager A, Heemstra L, Bhambra R, Ehlen J, Esser K, Paul K, et al.
Biochimie
. 2016 Dec;
132:161-165.
PMID: 27916643
Brain and muscle-ARNT-like factor (Bmal1/BMAL1) is an essential transcriptional/translational factor of circadian clocks. Loss of function of Bmal1/BMAL1 is highly disruptive to physiological and behavioral processes. In light of these...
9.
Brager A, Yang T, Ehlen J, Simon R, Meller R, Paul K
Sleep
. 2016 Aug;
39(11):2033-2040.
PMID: 27568798
Study Objectives: Episodes of brief limb ischemia (remote preconditioning) in mice induce tolerance to modeled ischemic stroke (focal brain ischemia). Since stroke outcomes are in part dependent on sleep-wake history,...
10.
Ehlen J, Jones K, Pinckney L, Gray C, Burette S, Weinberg R, et al.
J Neurosci
. 2015 Oct;
35(40):13587-98.
PMID: 26446213
Significance Statement: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by loss of expression of the maternal copy of the UBE3A gene. Individuals with AS have severe sleep dysfunction...