Radioprotectors and Mitigators of Radiation-induced Normal Tissue Injury

Overview

Journal Oncologist

Publisher Oxford University Press

Specialty Oncology

Date 2010 Apr 24

PMID 20413641

Citations 177

Authors

Deborah Citrin

Ana P Cotrim

Fuminori Hyodo

Bruce J Baum

Murali C Krishna

James B Mitchell

Affiliations

Soon will be listed here.

Abstract

Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue to radiation may result in both acute and chronic toxicities that can result in an inability to deliver the intended therapy, a range of symptoms, and a decrease in quality of life. Radioprotectors are compounds that are designed to reduce the damage in normal tissues caused by radiation. These compounds are often antioxidants and must be present before or at the time of radiation for effectiveness. Other agents, termed mitigators, may be used to minimize toxicity even after radiation has been delivered. Herein, we review agents in clinical use or in development as radioprotectors and mitigators of radiation-induced normal tissue injury. Few agents are approved for clinical use, but many new compounds show promising results in preclinical testing.

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