Mouse Models for Type 1 Diabetes

Overview

Journal Drug Discov Today Dis Models

Publisher Elsevier

Date 2010 Apr 22

PMID 20407588

Citations 52

Authors

T L Van Belle

P Taylor

M G von Herrath

Affiliations

Soon will be listed here.

Abstract

Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researchers to zoom in on specific aspects of this complex disease. In this review, we provide an overview of currently available mouse models for T1D.

Citing Articles

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Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.

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MiR-144-5p and miR-21-5p do not drive bone disease in a mouse model of type 1 diabetes mellitus.

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