Isolation of Maxadilan, a Potent Vasodilatory Peptide from the Salivary Glands of the Sand Fly Lutzomyia Longipalpis

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1991 Jun 15

PMID 2040631

Citations 57

Authors

E A Lerner

J M Ribeiro

R J Nelson

M R Lerner

Affiliations

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Abstract

Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan.

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