Spermatogonial Stem Cell Regulation and Spermatogenesis

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2010 Apr 21

PMID 20403877

Citations 177

Authors

Bart T Phillips

Kathrin Gassei

Kyle E Orwig

Affiliations

Soon will be listed here.

Abstract

This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools to enhance our understanding of stem cell biology and spermatogenesis. Increased knowledge about the biology of SSCs improves our capacity to manipulate these cells for practical application. The chapter concludes with a discussion of future directions for fundamental investigation and practical applications of SSCs.

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References

Suzuki H, Sada A, Yoshida S, Saga Y . The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol. 2009; 336(2):222-31. DOI: 10.1016/j.ydbio.2009.10.002. View

Toyooka Y, Tsunekawa N, Takahashi Y, Matsui Y, Satoh M, Noce T . Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development. Mech Dev. 2000; 93(1-2):139-49. DOI: 10.1016/s0925-4773(00)00283-5. View

Ballow D, Meistrich M, Matzuk M, Rajkovic A . Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006; 294(1):161-7. DOI: 10.1016/j.ydbio.2006.02.027. View

Yoshida S, Takakura A, Ohbo K, Abe K, Wakabayashi J, Yamamoto M . Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Dev Biol. 2004; 269(2):447-58. DOI: 10.1016/j.ydbio.2004.01.036. View

Braydich-Stolle L, Kostereva N, Dym M, Hofmann M . Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol. 2007; 304(1):34-45. PMC: 2077853. DOI: 10.1016/j.ydbio.2006.12.013. View

Costoya J, Hobbs R, Barna M, Cattoretti G, Manova K, Sukhwani M . Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet. 2004; 36(6):653-9. DOI: 10.1038/ng1367. View

Elling U, Klasen C, Eisenberger T, Anlag K, Treier M . Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 2006; 103(44):16319-24. PMC: 1637580. DOI: 10.1073/pnas.0607884103. View

Kim Y, Turner D, Nelson J, Dobrinski I, McEntee M, Travis A . Production of donor-derived sperm after spermatogonial stem cell transplantation in the dog. Reproduction. 2008; 136(6):823-31. PMC: 2706094. DOI: 10.1530/REP-08-0226. View

Brinster R, Avarbock M . Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci U S A. 1994; 91(24):11303-7. PMC: 45219. DOI: 10.1073/pnas.91.24.11303. View

10.

ROOSEN-RUNGE E, GIESEL Jr L . Quantitative studies on spermatogenesis in the albino rat. Am J Anat. 1950; 87(1):1-30. DOI: 10.1002/aja.1000870102. View

11.

Brinster R, Zimmermann J . Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci U S A. 1994; 91(24):11298-302. PMC: 45218. DOI: 10.1073/pnas.91.24.11298. View

12.

Yoshida S, Sukeno M, Nabeshima Y . A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science. 2007; 317(5845):1722-6. DOI: 10.1126/science.1144885. View

13.

Kanatsu-Shinohara M, Ogonuki N, Inoue K, Ogura A, Toyokuni S, Shinohara T . Restoration of fertility in infertile mice by transplantation of cryopreserved male germline stem cells. Hum Reprod. 2003; 18(12):2660-7. DOI: 10.1093/humrep/deg483. View

14.

Dettin L, Ravindranath N, Hofmann M, Dym M . Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod. 2003; 69(5):1565-71. DOI: 10.1095/biolreprod.103.016394. View

15.

Kanatsu-Shinohara M, Miki H, Inoue K, Ogonuki N, Toyokuni S, Ogura A . Germline niche transplantation restores fertility in infertile mice. Hum Reprod. 2005; 20(9):2376-82. DOI: 10.1093/humrep/dei096. View

16.

Orwig K, Schlatt S . Cryopreservation and transplantation of spermatogonia and testicular tissue for preservation of male fertility. J Natl Cancer Inst Monogr. 2005; (34):51-6. DOI: 10.1093/jncimonographs/lgi029. View

17.

Schlatt S, Ehmcke J, Jahnukainen K . Testicular stem cells for fertility preservation: preclinical studies on male germ cell transplantation and testicular grafting. Pediatr Blood Cancer. 2009; 53(2):274-80. DOI: 10.1002/pbc.22002. View

18.

Yoshinaga K, Ogawa M, Hayashi S, Kunisada T, Fujimoto T, Nishikawa S . Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development. 1991; 113(2):689-99. DOI: 10.1242/dev.113.2.689. View

19.

Ying Y, Qi X, Zhao G . Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways. Proc Natl Acad Sci U S A. 2001; 98(14):7858-62. PMC: 35432. DOI: 10.1073/pnas.151242798. View

20.

Koshimizu U, Nishioka H, Watanabe D, Dohmae K, Nishimune Y . Characterization of a novel spermatogenic cell antigen specific for early stages of germ cells in mouse testis. Mol Reprod Dev. 1995; 40(2):221-7. DOI: 10.1002/mrd.1080400211. View