Nanomicellar Formulations for Sustained Drug Delivery: Strategies and Underlying Principles

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2010 Apr 17

PMID 20394539

Citations 94

Authors

Ruchit Trivedi

Uday B Kompella

Affiliations

Soon will be listed here.

Abstract

Micellar delivery systems smaller than 100 nm can be readily prepared. While micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. Thus, sustained drug delivery from micellar nanocarriers is a challenge. This article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. Comparisons are made with other competing delivery systems such as polymeric microparticles and nanoparticles. Amphiphilic molecules self-assemble in appropriate liquid media to form nanoscale micelles. Strategies for sustained release nanomicellar carriers include use of prodrugs, drug polymer conjugates, novel polymers with low critical micellar concentration or of a reverse thermoresponsive nature, reverse micelles, multi-layer micelles with layer by layer assembly, polymeric films capable of forming micelles in vivo and micelle coats on a solid support. These new micellar systems are promising for sustained drug delivery.

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References

Yoo H, Park T . Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Release. 2001; 70(1-2):63-70. DOI: 10.1016/s0168-3659(00)00340-0. View

Prabaharan M, Grailer J, Pilla S, Steeber D, Gong S . Amphiphilic multi-arm block copolymer based on hyperbranched polyester, poly(L-lactide) and poly(ethylene glycol) as a drug delivery carrier. Macromol Biosci. 2008; 9(5):515-24. DOI: 10.1002/mabi.200800269. View

Zhang Z, Grijpma D, Feijen J . Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles. J Control Release. 2006; 112(1):57-63. DOI: 10.1016/j.jconrel.2006.01.010. View

Raghuvanshi R, Singh O, Panda A . Formulation and characterization of immunoreactive tetanus toxoid biodegradable polymer particles. Drug Deliv. 2001; 8(2):99-106. DOI: 10.1080/107175401750177089. View

Mugabe C, Hadaschik B, Kainthan R, Brooks D, So A, Gleave M . Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy. BJU Int. 2008; 103(7):978-86. DOI: 10.1111/j.1464-410X.2008.08132.x. View

Forrest M, Yanez J, Remsberg C, Ohgami Y, Kwon G, Davies N . Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity. Pharm Res. 2007; 25(1):194-206. PMC: 4872624. DOI: 10.1007/s11095-007-9451-9. View

Wang Y, Li Y, Wang Q, Fang X . Pharmacokinetics and biodistribution of polymeric micelles of paclitaxel with pluronic P105/poly(caprolactone) copolymers. Pharmazie. 2008; 63(6):446-52. View

Kim T, Lee H, Jang Y, Park T . Controlled release of paclitaxel from heparinized metal stent fabricated by layer-by-layer assembly of polylysine and hyaluronic acid-g-poly(lactic-co-glycolic acid) micelles encapsulating paclitaxel. Biomacromolecules. 2009; 10(6):1532-9. DOI: 10.1021/bm900116r. View

Wei X, Gong C, Shi S, Fu S, Men K, Zeng S . Self-assembled honokiol-loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymer. Int J Pharm. 2008; 369(1-2):170-5. DOI: 10.1016/j.ijpharm.2008.10.027. View

10.

Kuroda J, Kuratsu J, Yasunaga M, Koga Y, Saito Y, Matsumura Y . Potent antitumor effect of SN-38-incorporating polymeric micelle, NK012, against malignant glioma. Int J Cancer. 2009; 124(11):2505-11. DOI: 10.1002/ijc.24171. View

11.

Lavasanifar A, Samuel J, Kwon G . The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-L-aspartamide). J Control Release. 2002; 79(1-3):165-72. DOI: 10.1016/s0168-3659(01)00537-5. View

12.

Xiangyang X, Ling L, Jianping Z, Shiyue L, Jie Y, Xiaojin Y . Preparation and characterization of N-succinyl-N'-octyl chitosan micelles as doxorubicin carriers for effective anti-tumor activity. Colloids Surf B Biointerfaces. 2007; 55(2):222-8. DOI: 10.1016/j.colsurfb.2006.12.006. View

13.

Kim B, Park S, Hammond P . Hydrogen-bonding layer-by-layer-assembled biodegradable polymeric micelles as drug delivery vehicles from surfaces. ACS Nano. 2009; 2(2):386-92. DOI: 10.1021/nn700408z. View

14.

Okuda T, Kawakami S, Higuchi Y, Satoh T, Oka Y, Yokoyama M . Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles. Int J Pharm. 2009; 373(1-2):100-6. DOI: 10.1016/j.ijpharm.2009.01.019. View

15.

Liu H, Farrell S, Uhrich K . Drug release characteristics of unimolecular polymeric micelles. J Control Release. 2000; 68(2):167-74. DOI: 10.1016/s0168-3659(00)00247-9. View

16.

Sartor O . Eligard: leuprolide acetate in a novel sustained-release delivery system. Urology. 2003; 61(2 Suppl 1):25-31. DOI: 10.1016/s0090-4295(02)02396-8. View

17.

Yang X, Zhu B, Dong T, Pan P, Shuai X, Inoue Y . Interactions between an anticancer drug and polymeric micelles based on biodegradable polyesters. Macromol Biosci. 2008; 8(12):1116-25. DOI: 10.1002/mabi.200800085. View

18.

Kompella U, Bandi N, Ayalasomayajula S . Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression. Invest Ophthalmol Vis Sci. 2003; 44(3):1192-201. DOI: 10.1167/iovs.02-0791. View

19.

Determan M, Cox J, Mallapragada S . Drug release from pH-responsive thermogelling pentablock copolymers. J Biomed Mater Res A. 2006; 81(2):326-33. DOI: 10.1002/jbm.a.30991. View

20.

Dong H, Xu Q, Li Y, Mo S, Cai S, Liu L . The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release. Colloids Surf B Biointerfaces. 2008; 66(1):26-33. DOI: 10.1016/j.colsurfb.2008.05.007. View