Artificial Cell Microencapsulated Stem Cells in Regenerative Medicine, Tissue Engineering and Cell Therapy

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2010 Apr 14

PMID 20384219

Citations 6

Authors

Zun Chang Liu

Thomas Ming Swi Chang

Affiliations

Soon will be listed here.

Abstract

Adult stem cells, especially isolated from bone marrow, have been extensively investigated in recent years. Studies focus on their multiple plasticity oftransdifferentiating into various cell lineages and on their potential in cellular therapy in regenerative medicine. In many cases, there is the need for tissue engineering manipulation. Among the different approaches of stem cells tissue engineering, microencapsulation can immobilize stem cells to provide a favorable microenvironment for stem cells survival and functioning. Furthermore, microencapsulated stem cells are immunoisolated after transplantation. We show that one intraperitoneal injection of microencapsulated bone marrow stem cells can prolong the survival of liver failure rat models with 90% of the liver removed surgically. In addition to transdifferentiation, bone marrow stem cells can act as feeder cells. For example, when coencapsulated with hepatocytes, stem cells can increase the viability and function of the hepatocytes in vitro and in vivo.

Citing Articles

Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions.

Todd E, Mirsky N, Silva B, Shinde A, Arakelians A, Nayak V J Funct Biomater. 2024; 15(10).

PMID: 39452579 PMC: 11509029. DOI: 10.3390/jfb15100280.

Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation.

Mooranian A, Jones M, Ionescu C, Walker D, Wagle S, Kovacevic B J Funct Biomater. 2021; 12(4).

PMID: 34940547 PMC: 8704355. DOI: 10.3390/jfb12040068.

Artificial cells: from basic science to applications.

Xu C, Hu S, Chen X Mater Today (Kidlington). 2017; 19(9):516-532.

PMID: 28077925 PMC: 5222523. DOI: 10.1016/j.mattod.2016.02.020.

Heart regeneration with engineered myocardial tissue.

Coulombe K, Bajpai V, Andreadis S, Murry C Annu Rev Biomed Eng. 2014; 16:1-28.

PMID: 24819474 PMC: 4213953. DOI: 10.1146/annurev-bioeng-071812-152344.

Artificial Cells Containing Stem Cells for Liver Failure.

Chang T Asia Pac Biotech News. 2013; 14(3):17-19.

PMID: 23569329 PMC: 3618433.

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