Nutraceutical Augmentation of Circulating Endothelial Progenitor Cells and Hematopoietic Stem Cells in Human Subjects

Overview

Journal J Transl Med

Publisher Biomed Central

Specialties Biomedical Engineering
General Medicine

Date 2010 Apr 10

PMID 20377846

Citations 5

Authors

Nina A Mikirova

James A Jackson

Ron Hunninghake

Julian Kenyon

Kyle W H Chan

Cathy A Swindlehurst

Boris Minev

Amit N Patel

Michael P Murphy

Leonard Smith

Famela Ramos

Thomas E Ichim

Neil H Riordan

Affiliations

Soon will be listed here.

Abstract

The medical significance of circulating endothelial or hematopoietic progenitors is becoming increasing recognized. While therapeutic augmentation of circulating progenitor cells using G-CSF has resulted in promising preclinical and early clinical data for several degenerative conditions, this approach is limited by cost and inability to perform chronic administration. Stem-Kine is a food supplement that was previously reported to augment circulating EPC in a pilot study. Here we report a trial in 18 healthy volunteers administered Stem-Kine twice daily for a 2 week period. Significant increases in circulating CD133 and CD34 cells were observed at days 1, 2, 7, and 14 subsequent to initiation of administration, which correlated with increased hematopoietic progenitors as detected by the HALO assay. Augmentation of EPC numbers in circulation was detected by KDR-1/CD34 staining and colony forming assays. These data suggest Stem-Kine supplementation may be useful as a stimulator of reparative processes associated with mobilization of hematopoietic and endothelial progenitors.

Citing Articles

Hematopoietic Stem Cell: Regulation and Nutritional Intervention.

Sun S, Han Y, Lei Y, Yu Y, Dong Y, Chen J Nutrients. 2023; 15(11).

PMID: 37299568 PMC: 10255666. DOI: 10.3390/nu15112605.

Markers and Biomarkers of Endothelium: When Something Is Rotten in the State.

Goncharov N, Nadeev A, Jenkins R, Avdonin P Oxid Med Cell Longev. 2018; 2017:9759735.

PMID: 29333215 PMC: 5733214. DOI: 10.1155/2017/9759735.

Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood.

Mikirova N, Kesari S, Ichim T, Riordan N J Transl Med. 2017; 15(1):213.

PMID: 29058588 PMC: 5651612. DOI: 10.1186/s12967-017-1315-4.

Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients.

Mirzaei A, Tavoosidana G, Modarressi M, Rad A, Fazeli M, Shirkoohi R Tumour Biol. 2015; 36(6):4801-10.

PMID: 25631749 DOI: 10.1007/s13277-015-3132-9.

Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?.

Mansilla E, Aquino V, Zambon D, Marin G, Martire K, Roque G Stem Cells Int. 2011; 2011:943216.

PMID: 21716667 PMC: 3118295. DOI: 10.4061/2011/943216.

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