Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2010 Apr 8

PMID 20371545

Citations 49

Authors

Robin K Minor

Joanne S Allard

Caitlin M Younts

Theresa M Ward

Rafael de Cabo

Affiliations

Soon will be listed here.

Abstract

The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)-which is well known to improve both health and longevity in controlled studies-as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.

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