The Enhancement of Stress-related Memory by Glucocorticoids Depends on Synapsin-Ia/Ib

Overview

Journal Mol Psychiatry

Specialties Molecular Biology
Psychiatry

Date 2010 Apr 7

PMID 20368707

Citations 44

Authors

J-M Revest

N Kaouane

M Mondin

A Le Roux

F Rouge-Pont

M Vallee

J Barik

F Tronche

A Desmedt

P V Piazza

Affiliations

Soon will be listed here.

Abstract

The activation of glucocorticoid receptors (GR) by glucocorticoids increases stress-related memory through the activation of the MAPK signaling pathway and the downstream transcription factor Egr-1. Here, using converging in vitro and in vivo approaches, respectively, GR-expressing cell lines, culture of hippocampal neurons, and GR genetically modified mice (GR(NesCre)), we identified synapsin-Ia/Ib as one of the effectors of the glucocorticoid signaling cascade. Stress and glucocorticoid-induced activation of the GR modulate synapsin-Ia/Ib through two complementary mechanisms. First, glucocorticoids driving Egr-1 expression increase the expression of synapsin-Ia/Ib, and second, glucocorticoids driving MAPK activation increase its phosphorylation. Finally, we showed that blocking fucosylation of synapsin-Ia/Ib in the hippocampus inhibits its expression and prevents the glucocorticoid-mediated increase in stress-related memory. In conclusion, our data provide a complete molecular pathway (GR/Egr-1/MAPK/Syn-Ia/Ib) through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress.

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