Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Overview

Journal Open Cardiovasc Med J

Publisher Bentham Open

Specialty Cardiology & Vascular Diseases

Date 2010 Apr 3

PMID 20361002

Citations 33

Authors

George S Metsios

Antonios Stavropoulos-Kalinoglou

Aamer Sandoo

Jet J C S Veldhuijzen van Zanten

Tracey E Toms

Holly John

George D Kitas

Affiliations

Soon will be listed here.

Abstract

Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.

Citing Articles

Economic and Humanistic Burden of Rheumatoid Arthritis: Results From the US National Survey Data 2018-2020.

Huang Y, Li J, Agarwal S ACR Open Rheumatol. 2024; 6(11):746-754.

PMID: 39105293 PMC: 11557984. DOI: 10.1002/acr2.11728.

Association between choroidal thickness and interstitial lung disease in patients with rheumatoid arthritis: A cross-sectional study.

Kaymaz S, Savurmus N, Karasu U, Kaya H, Ufuk F, Utebey A Arch Rheumatol. 2024; 39(1):89-98.

PMID: 38774707 PMC: 11104761. DOI: 10.46497/ArchRheumatol.2023.10116.

Elevated APE1/Ref-1 Levels of Synovial Fluids in Patients with Rheumatoid Arthritis: Reflection of Disease Activity.

Yoo I, Lee Y, Kang S, Kim J, Joo H, Yoo S J Clin Med. 2021; 10(22).

PMID: 34830606 PMC: 8621376. DOI: 10.3390/jcm10225324.

Objective measurement of sedentary time and physical activity in people with rheumatoid arthritis: protocol for an accelerometer and activPAL validation study.

OBrien C, Duda J, Kitas G, Veldhuijzen van Zanten J, Metsios G, Fenton S Mediterr J Rheumatol. 2020; 30(2):125-134.

PMID: 32185353 PMC: 7045970. DOI: 10.31138/mjr.30.2.125.

The Impact of Exercise, Lifestyle, and Clinical Factors on Perceived Cognitive Function in Patients with Rheumatoid Arthritis: Results from a Prospective Cohort Study.

Shadick N, Katz P, Iannaccone C, Maica G, Coblyn J, Weinblatt M ACR Open Rheumatol. 2019; 1(10):620-626.

PMID: 31872183 PMC: 6917307. DOI: 10.1002/acr2.11088.

References

Yang H, Prior B, Lloyd P, Taylor J, Li Z, Laughlin M . Training-induced vascular adaptations to ischemic muscle. J Physiol Pharmacol. 2009; 59 Suppl 7:57-70. PMC: 2654575. View

Laughlin M, Roseguini B . Mechanisms for exercise training-induced increases in skeletal muscle blood flow capacity: differences with interval sprint training versus aerobic endurance training. J Physiol Pharmacol. 2009; 59 Suppl 7:71-88. PMC: 2654584. View

Landmesser U, Hornig B, Drexler H . Endothelial function: a critical determinant in atherosclerosis?. Circulation. 2004; 109(21 Suppl 1):II27-33. DOI: 10.1161/01.CIR.0000129501.88485.1f. View

Gonzalez M, Selwyn A . Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med. 2003; 115 Suppl 8A:99S-106S. DOI: 10.1016/j.amjmed.2003.09.016. View

Hambrecht R, Walther C, Mobius-Winkler S, Gielen S, Linke A, Conradi K . Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004; 109(11):1371-8. DOI: 10.1161/01.CIR.0000121360.31954.1F. View

Iademarco M, Barks J, Dean D . Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells. J Clin Invest. 1995; 95(1):264-71. PMC: 295423. DOI: 10.1172/JCI117650. View

Metsios G, Stavropoulos-Kalinoglou A, Veldhuijzen van Zanten J, Treharne G, Panoulas V, Douglas K . Rheumatoid arthritis, cardiovascular disease and physical exercise: a systematic review. Rheumatology (Oxford). 2007; 47(3):239-48. DOI: 10.1093/rheumatology/kem260. View

Abbasi F, Brown Jr B, Lamendola C, McLaughlin T, Reaven G . Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol. 2002; 40(5):937-43. DOI: 10.1016/s0735-1097(02)02051-x. View

Metsios G, Stavropoulos-Kalinoglou A, Panoulas V, Wilson M, Nevill A, Koutedakis Y . Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. Eur J Cardiovasc Prev Rehabil. 2009; 16(2):188-94. DOI: 10.1097/HJR.0b013e3283271ceb. View

10.

Hahn B, Grossman J, Chen W, McMahon M . The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun. 2007; 28(2-3):69-75. DOI: 10.1016/j.jaut.2007.02.004. View

11.

Geffken D, Cushman M, Burke G, Polak J, Sakkinen P, Tracy R . Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol. 2001; 153(3):242-50. DOI: 10.1093/aje/153.3.242. View

12.

Sattar N, McCarey D, Capell H, McInnes I . Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation. 2003; 108(24):2957-63. DOI: 10.1161/01.CIR.0000099844.31524.05. View

13.

Munneke M, de Jong Z, Zwinderman A, Ronday H, van den Ende C, Vlieland T . High intensity exercise or conventional exercise for patients with rheumatoid arthritis? Outcome expectations of patients, rheumatologists, and physiotherapists. Ann Rheum Dis. 2004; 63(7):804-8. PMC: 1755060. DOI: 10.1136/ard.2003.011189. View

14.

Handschin C, Spiegelman B . The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 2008; 454(7203):463-9. PMC: 2587487. DOI: 10.1038/nature07206. View

15.

Malek A, Izumo S . Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol. 1992; 263(2 Pt 1):C389-96. DOI: 10.1152/ajpcell.1992.263.2.C389. View

16.

Fichtlscherer S, Rossig L, Breuer S, Vasa M, Dimmeler S, Zeiher A . Tumor necrosis factor antagonism with etanercept improves systemic endothelial vasoreactivity in patients with advanced heart failure. Circulation. 2001; 104(25):3023-5. DOI: 10.1161/hc5001.101749. View

17.

Verma S, Li S, Badiwala M, Weisel R, Fedak P, Li R . Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation. 2002; 105(16):1890-6. DOI: 10.1161/01.cir.0000015126.83143.b4. View

18.

Schindler R, Mancilla J, Endres S, Ghorbani R, Clark S, Dinarello C . Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 1990; 75(1):40-7. View

19.

Himburg H, Dowd S, Friedman M . Frequency-dependent response of the vascular endothelium to pulsatile shear stress. Am J Physiol Heart Circ Physiol. 2007; 293(1):H645-53. DOI: 10.1152/ajpheart.01087.2006. View

20.

Qamirani E, Ren Y, Kuo L, Hein T . C-reactive protein inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by activating p38 kinase and NAD(P)H oxidase. Arterioscler Thromb Vasc Biol. 2005; 25(5):995-1001. DOI: 10.1161/01.ATV.0000159890.10526.1e. View