Mouse Models of Myelodysplastic Syndromes

Overview

Journal Hematol Oncol Clin North Am

Specialties Hematology
Oncology

Date 2010 Apr 3

PMID 20359631

Citations 19

Authors

Sarah H Beachy

Peter D Aplan

Affiliations

Soon will be listed here.

Abstract

Three general approaches have been used to model myelodysplastic syndrome (MDS) in mice, including treatment with mutagens or carcinogens, xenotransplantation of human MDS cells, and genetic engineering of mouse hematopoietic cells. This article discusses the phenotypes observed in available mouse models for MDS with a concentration on a model that leads to aberrant expression of conserved homeobox genes that are important regulators of normal hematopoiesis. Using these models of MDS should allow a more complete understanding of the disease process and provide a platform for preclinical testing of therapeutic approaches.

Citing Articles

Mesenchymal Stem Cells in Myelodysplastic Syndromes and Leukaemia.

Eroz I, Kakkar P, Lazar R, El-Jawhari J Biomedicines. 2024; 12(8).

PMID: 39200142 PMC: 11351218. DOI: 10.3390/biomedicines12081677.

Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia.

Mei Y, Ren K, Liu Y, Ma A, Xia Z, Han X J Clin Invest. 2022; 132(17).

PMID: 35900794 PMC: 9435651. DOI: 10.1172/JCI152673.

The Coming of Age of Preclinical Models of MDS.

Liu W, Teodorescu P, Halene S, Ghiaur G Front Oncol. 2022; 12:815037.

PMID: 35372085 PMC: 8966105. DOI: 10.3389/fonc.2022.815037.

Novel spontaneous myelodysplastic syndrome mouse model.

Li W, Cao L, Li M, Yang X, Zhang W, Song Z Animal Model Exp Med. 2021; 4(2):169-180.

PMID: 34179724 PMC: 8212821. DOI: 10.1002/ame2.12168.

Summary of animal models of myelodysplastic syndrome.

Li W, Li M, Yang X, Zhang W, Cao L, Gao R Animal Model Exp Med. 2021; 4(1):71-76.

PMID: 33738439 PMC: 7954832. DOI: 10.1002/ame2.12144.

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