Circadian Disruption Induced by Light-at-night Accelerates Aging and Promotes Tumorigenesis in Young but Not in Old Rats

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2010 Apr 1

PMID 20354269

Citations 13

Authors

Irina A Vinogradova

Vladimir N Anisimov

Andrey V Bukalev

Viktor A Ilyukha

Evgeniy A Khizhkin

Tatiana A Lotosh

Anna V Semenchenko

Mark A Zabezhinski

Affiliations

Soon will be listed here.

Abstract

We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months.

Citing Articles

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