Epithelial-mesenchymal Transitions and Hepatocarcinogenesis

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2010 Mar 26

PMID 20335655

Citations 56

Authors

Janice Jou

Anna Mae Diehl

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.

Citing Articles

Identification of vessels encapsulating tumor clusters in solitary hepatocellular carcinoma via imaging biomarkers in preoperative contrast-enhanced magnetic resonance imaging.

Li Z, Song W, Zhang J, Li Q, Song Z, Ren X Quant Imaging Med Surg. 2024; 14(12):8586-8600.

PMID: 39698687 PMC: 11652036. DOI: 10.21037/qims-24-315.

CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming.

Liu S, Zhang S, Dong H, Jin X, Sun J, Zhou H BMC Cancer. 2024; 24(1):698.

PMID: 38849760 PMC: 11157766. DOI: 10.1186/s12885-024-12472-7.

Plumbagin Regulates Snail to Inhibit Hepatocellular Carcinoma Epithelial-Mesenchymal Transition in vivo and in vitro.

Du Y, Yuan B, Ye Y, Zhou F, Liu H, Huang J J Hepatocell Carcinoma. 2024; 11:565-580.

PMID: 38525157 PMC: 10960549. DOI: 10.2147/JHC.S452924.

Construction of a prognostic prediction model in liver cancer based on genes involved in integrin cell surface interactions pathway by multi-omics screening.

Yu X, Zhang H, Li J, Gu L, Cao L, Gong J Front Cell Dev Biol. 2024; 12:1237445.

PMID: 38374893 PMC: 10875080. DOI: 10.3389/fcell.2024.1237445.

Functional Enrichment Analysis of Tumor Microenvironment-Driven Molecular Alterations That Facilitate Epithelial-to-Mesenchymal Transition and Distant Metastasis.

Abdolahi M, Talkhounche P, Nazari M, Hosseininia H, Khoshdel-Rad N, Sadrabadi A Bioinform Biol Insights. 2024; 18:11779322241227722.

PMID: 38318286 PMC: 10840405. DOI: 10.1177/11779322241227722.

References

Sun T, Zhao N, Zhao X, Gu Q, Zhang S, Che N . Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology. 2009; 51(2):545-56. DOI: 10.1002/hep.23311. View

Acloque H, Adams M, Fishwick K, Bronner-Fraser M, Nieto M . Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest. 2009; 119(6):1438-49. PMC: 2689100. DOI: 10.1172/JCI38019. View

Sicklick J, Li Y, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P . Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis. 2005; 27(4):748-57. DOI: 10.1093/carcin/bgi292. View

Witek R, Yang L, Liu R, Jung Y, Omenetti A, Syn W . Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2008; 136(1):320-330.e2. PMC: 3724240. DOI: 10.1053/j.gastro.2008.09.066. View

Murata K, Suzuki H, Okano H, Oyamada T, Yasuda Y, Sakamoto A . Hypoxia-induced des-gamma-carboxy prothrombin production in hepatocellular carcinoma. Int J Oncol. 2009; 36(1):161-70. View

Zeisberg M, Neilson E . Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009; 119(6):1429-37. PMC: 2689132. DOI: 10.1172/JCI36183. View

Sackett S, Li Z, Hurtt R, Gao Y, Wells R, Brondell K . Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology. 2008; 49(3):920-9. PMC: 2931830. DOI: 10.1002/hep.22705. View

Parkin D . Global cancer statistics in the year 2000. Lancet Oncol. 2002; 2(9):533-43. DOI: 10.1016/S1470-2045(01)00486-7. View

Hall A . Rho GTPases and the control of cell behaviour. Biochem Soc Trans. 2005; 33(Pt 5):891-5. DOI: 10.1042/BST20050891. View

10.

Taura K, Miura K, Iwaisako K, Osterreicher C, Kodama Y, Penz-Osterreicher M . Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010; 51(3):1027-36. PMC: 2906231. DOI: 10.1002/hep.23368. View

11.

Wells R . The epithelial-to-mesenchymal transition in liver fibrosis: here today, gone tomorrow?. Hepatology. 2010; 51(3):737-40. PMC: 3247701. DOI: 10.1002/hep.23529. View

12.

Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F . ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene. 2008; 28(5):638-50. PMC: 2900603. DOI: 10.1038/onc.2008.418. View

13.

Kalluri R, Weinberg R . The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119(6):1420-8. PMC: 2689101. DOI: 10.1172/JCI39104. View

14.

Yang M, Chen C, Chau G, Chiou S, Su C, Chou T . Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology. 2009; 50(5):1464-74. DOI: 10.1002/hep.23221. View

15.

Battaglia S, Benzoubir N, Nobilet S, Charneau P, Samuel D, Zignego A . Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS One. 2009; 4(2):e4355. PMC: 2629560. DOI: 10.1371/journal.pone.0004355. View

16.

Edwards B, Ward E, Kohler B, Eheman C, Zauber A, Anderson R . Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer. 2009; 116(3):544-73. PMC: 3619726. DOI: 10.1002/cncr.24760. View

17.

Katoh Y, Katoh M . Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med. 2008; 22(3):271-5. View

18.

Slany A, Haudek V, Zwickl H, Gundacker N, Grusch M, Weiss T . Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B. J Proteome Res. 2009; 9(1):6-21. DOI: 10.1021/pr900057t. View

19.

Lee S, Ryu H, Kim Y, Choi S, Lee M, Kwak T . Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. Hepatology. 2009; 49(4):1316-25. DOI: 10.1002/hep.22777. View

20.

Min A, Choi J, Woo H, Kim J, Kwon J, Bae S . High expression of Snail mRNA in blood from hepatocellular carcinoma patients with extra-hepatic metastasis. Clin Exp Metastasis. 2009; 26(7):759-67. DOI: 10.1007/s10585-009-9275-6. View