Epithelial-stromal Interaction in Squamous Cell Epithelium-derived Tumors: an Important New Player in the Control of Tumor Biological Properties

Overview

Journal Anticancer Res

Specialty Oncology

Date 2010 Mar 25

PMID 20332454

Citations 11

Authors

Jan Plzak

Lukas Lacina

Martin Chovanec

Barbora Dvorankova

Pavol Szabo

Zdenek cada

Karel Smetana Jr

Affiliations

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Abstract

Mesenchymal-epithelial interaction is important in the morphogenesis of squamous epithelia and their appendages, and in the control of the hair cycle postnatally. This review summarizes data regarding the interaction between stromal fibroblasts and tumor cells, with an emphasis on tumors originating from squamous epithelium. Tumor stromal fibroblasts as important element of the cancer stem cell niche are able to participate in the control of the biological properties of tumors. We propose these stromal cells and their products as novel targets for anticancer therapy.

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