Aberrant DNA Methylation of Imprinted H19 Gene in Human Preimplantation Embryos

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2010 Mar 23

PMID 20303482

Citations 15

Authors

Shi-Ling Chen

Xiao-Yun Shi

Hai-Yan Zheng

Fang-Rong Wu

Chen Luo

Affiliations

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Abstract

DNA methylation patterns of the H19 differentially methylated region were successfully determined in 32 of 50 human day 3 embryos produced and discarded after assisted reproductive technology procedures. We found methylation patterns similar to those of somatic cells in 81.3% of embryos and demethylation or hypomethylation patterns in 18.7% of embryos.

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