Buccal Drug Delivery of Pravastatin Sodium

Overview

Journal AAPS PharmSciTech

Publisher Springer

Specialty Pharmacology

Date 2010 Mar 20

PMID 20300898

Citations 15

Authors

Supriya S Shidhaye

Pritesh V Thakkar

Neha M Dand

Vilasrao J Kadam

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal tablets of pravastatin sodium using carrageenan gum as the base matrix. The tablets were prepared by direct compression method. Polyvinyl pyrrolidone (PVP) K 30, Pluronic(R) F 127, and magnesium oxide were used to improve tablet properties. Magnesium stearate, talc, and lactose were used to aid the compression of tablets. The tablets were found to have good appearance, uniform thickness, diameter, weight, pH, and drug content. A 2(3) full factorial design was employed to study the effect of independent variables viz. levels of carrageenan gum, Pluronic F 127 and PVP K30, which significantly influenced characteristics like in vitro mucoadhesive strength, in vitro drug release, swelling index, and in vitro residence time. The tablet was coated with an impermeable backing layer of ethyl cellulose to ensure unidirectional drug release. Different penetration enhancers were tried to improve the permeation of pravastatin sodium through buccal mucosa. Formulation containing 1% sodium lauryl sulfate showed good permeation of pravastatin sodium through mucosa. Histopathological studies revealed no buccal mucosal damage. It can be concluded that buccal route can be one of the alternatives available for the administration of pravastatin sodium.

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References

Nafee N, Ismail F, Boraie N, Mortada L . Mucoadhesive delivery systems. II. Formulation and in-vitro/in-vivo evaluation of buccal mucoadhesive tablets containing water-soluble drugs. Drug Dev Ind Pharm. 2004; 30(9):995-1004. DOI: 10.1081/ddc-200037226. View

Choi H, Kim C . Development of omeprazole buccal adhesive tablets with stability enhancement in human saliva. J Control Release. 2000; 68(3):397-404. DOI: 10.1016/s0168-3659(00)00276-5. View

Bodmeier R, Paeratakul O . Evaluation of drug-containing polymer films prepared from aqueous latexes. Pharm Res. 1989; 6(8):725-30. DOI: 10.1023/a:1015950825398. View

Rossi S, Sandri G, Ferrari F, Bonferoni M, Caramella C . Buccal delivery of acyclovir from films based on chitosan and polyacrylic acid. Pharm Dev Technol. 2003; 8(2):199-208. DOI: 10.1081/pdt-120018490. View

Dortunc B, Ozer L, Uyanik N . Development and in vitro evaluation of a buccoadhesive pindolol tablet formulation. Drug Dev Ind Pharm. 1999; 24(3):281-8. DOI: 10.3109/03639049809085621. View

Piyakulawat P, Praphairaksit N, Chantarasiri N, Muangsin N . Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac. AAPS PharmSciTech. 2008; 8(4):E97. PMC: 2750683. DOI: 10.1208/pt0804097. View

Choi H, Jung J, Yong C, Rhee C, Lee M, Han J . Formulation and in vivo evaluation of omeprazole buccal adhesive tablet. J Control Release. 2000; 68(3):405-12. DOI: 10.1016/s0168-3659(00)00275-3. View

Shojaei A . Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci. 2000; 1(1):15-30. View

Mashru R, Sutariya V, Sankalia M, Sankalia J . Transbuccal delivery of lamotrigine across porcine buccal mucosa: in vitro determination of routes of buccal transport. J Pharm Pharm Sci. 2005; 8(1):54-62. View

10.

Jain A, Aungst B, Adeyeye M . Development and in vivo evaluation of buccal tablets prepared using danazol-sulfobutylether 7 beta-cyclodextrin (SBE 7) complexes. J Pharm Sci. 2002; 91(7):1659-68. DOI: 10.1002/jps.10163. View

11.

Majithiya R, Ghosh P, Umrethia M, Murthy R . Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan. AAPS PharmSciTech. 2006; 7(3):67. PMC: 2750509. DOI: 10.1208/pt070367. View

12.

Gordon D, Schroeder M . Oral transmucosal fentanyl citrate--OTFC (ACTIQ) #103. J Palliat Med. 2008; 11(4):633-4. DOI: 10.1089/jpm.2008.9922. View

13.

Munasur A, Pillay V, Chetty D, Govender T . Statistical optimisation of the mucoadhesivity and characterisation of multipolymeric propranolol matrices for buccal therapy. Int J Pharm. 2006; 323(1-2):43-51. DOI: 10.1016/j.ijpharm.2006.05.051. View

14.

Senel S, Hincal A . Drug permeation enhancement via buccal route: possibilities and limitations. J Control Release. 2001; 72(1-3):133-44. DOI: 10.1016/s0168-3659(01)00269-3. View

15.

Patel V, Prajapati B, Patel J, Patel M . Physicochemical characterization and evaluation of buccal adhesive patches containing propranolol hydrochloride. Curr Drug Deliv. 2006; 3(3):325-31. DOI: 10.2174/156720106777731082. View

16.

El-Samaligy M, Yahia S, Basalious E . Formulation and evaluation of diclofenac sodium buccoadhesive discs. Int J Pharm. 2004; 286(1-2):27-39. DOI: 10.1016/j.ijpharm.2004.07.033. View

17.

Singh B, Chakkal S, Ahuja N . Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology. AAPS PharmSciTech. 2006; 7(1):E3. DOI: 10.1208/pt070103. View

18.

Shidhaye S, Saindane N, Sutar S, Kadam V . Mucoadhesive bilayered patches for administration of sumatriptan succinate. AAPS PharmSciTech. 2008; 9(3):909-16. PMC: 2977019. DOI: 10.1208/s12249-008-9125-x. View

19.

Abu-Huwaij R, Assaf S, Salem M, Sallam A . Potential mucoadhesive dosage form of lidocaine hydrochloride: II. In vitro and in vivo evaluation. Drug Dev Ind Pharm. 2007; 33(4):437-48. DOI: 10.1080/03639040601150211. View

20.

Alur H, Pather S, Mitra A, Johnston T . Transmucosal sustained-delivery of chlorpheniramine maleate in rabbits using a novel, natural mucoadhesive gum as an excipient in buccal tablets. Int J Pharm. 1999; 188(1):1-10. DOI: 10.1016/s0378-5173(99)00211-2. View