Enhanced Progenitor Cell Recruitment and Endothelial Repair After Selective Endothelial Injury of the Mouse Kidney

Overview

Journal Am J Physiol Renal Physiol

Publisher American Physiological Society

Specialties Nephrology
Physiology

Date 2010 Mar 19

PMID 20237239

Citations 15

Authors

Bernd Hohenstein

Mei-Chuan Kuo

Francesco Addabbo

Kaoru Yasuda

Brian Ratliff

Claudia Schwarzenberger

Kai-Uwe Eckardt

Christian P M Hugo

Michael S Goligorsky

Affiliations

Soon will be listed here.

Abstract

Primary and/or secondary injury of the renal microvascular endothelium is a common finding in various renal diseases. Besides well-known endothelial repair mechanisms, including endothelial cell (EC) proliferation and migration, homing of extrinsic cells such as endothelial progenitor cells (EPC) and hematopoietic stem cells (HSC) has been shown in various organs and may contribute to microvascular repair. However, these mechanisms have so far not been studied after selective microvascular injury in the kidney. The present study investigated the time course of EPC and HSC stimulation and homing following induction of selective EC injury in the mouse kidney along with various angiogenic factors potentially involved in EC repair and progenitor cell stimulation. Erythropoietin was used to stimulate progenitor cells in a therapeutic approach. We found that selective EC injury leads to a marked stimulation of EPCs, HSCs, and various angiogenic factors to orchestrate microvascular repair. Angiogenic factors started to increase as early as 30 min after disease induction. Progenitor cells could be first detected in the circulation and the spleen before they selectively homed to the diseased kidney. Injection of a high dose of erythropoietin 2 h after disease induction markedly attenuated vascular injury through nonhemodynamic mechanisms, possibly involving vascular endothelial growth factor release.

Citing Articles

Stem/progenitor cell in kidney: characteristics, homing, coordination, and maintenance.

Huang J, Kong Y, Xie C, Zhou L Stem Cell Res Ther. 2021; 12(1):197.

PMID: 33743826 PMC: 7981824. DOI: 10.1186/s13287-021-02266-0.

Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction.

Shen W, Chou Y, Huang H, Sheen J, Hung S, Chen H Stem Cell Res Ther. 2018; 9(1):344.

PMID: 30526689 PMC: 6288873. DOI: 10.1186/s13287-018-1092-x.

Endothelial colony-forming cells and pro-angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.

Basile D, Collett J, Yoder M Acta Physiol (Oxf). 2017; 222(2).

PMID: 28656611 PMC: 5745310. DOI: 10.1111/apha.12914.

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword.

Zhou D, Tan R, Fu H, Liu Y Lab Invest. 2015; 96(2):156-67.

PMID: 26692289 PMC: 4731262. DOI: 10.1038/labinvest.2015.153.

Extrarenal Progenitor Cells Do Not Contribute to Renal Endothelial Repair.

Sradnick J, Rong S, Luedemann A, Parmentier S, Bartaun C, Todorov V J Am Soc Nephrol. 2015; 27(6):1714-26.

PMID: 26453608 PMC: 4884107. DOI: 10.1681/ASN.2015030321.

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