Perspectives on Vaccines Against Varicella-zoster Virus Infections

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2010 Mar 17

PMID 20232192

Citations 21

Authors

Anne A Gershon

Michael D Gershon

Affiliations

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Abstract

Primary infection with varicella-zoster virus (VZV) results in varicella which, in populations where immunization is not used, occurs mostly in children. Varicella is a generalized rash illness with systemic features such as fever and malaise. During varicella, VZV becomes latent in sensory ganglia of the individual, and in 70% it remains asymptomatic for their lifetime. The remaining 30% develop reactivation from latency, resulting in herpes zoster (HZ). HZ usually occurs in persons over the age of 50, and is manifested by a painful unilateral rash that usually lasts about 2 weeks and then may be followed by a chronic pain syndrome called post-herpetic neuralgia (PHN). VZV infections are notoriously more severe in immunocompromised hosts than in healthy individuals. Despite gaps in our understanding of the details of immunity to VZV, successful vaccines have been developed against both varicella and zoster.

Citing Articles

Baculovirus Vector-Based Varicella-Zoster Virus Vaccine as a Promising Alternative with Enhanced Safety and Therapeutic Functions.

Lee C, Kim M, Chun J, Kim S, Yoon D, Lee H Vaccines (Basel). 2024; 12(3).

PMID: 38543967 PMC: 10975603. DOI: 10.3390/vaccines12030333.

Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis.

Thomsen M, Skouboe M, Mohlenberg M, Zhao J, de Keukeleere K, Heinz J J Clin Immunol. 2024; 44(2):56.

PMID: 38277122 PMC: 10817851. DOI: 10.1007/s10875-024-01653-5.

Current Methods for the Detection of Antibodies of Varicella-Zoster Virus: A Review.

Pan D, Wang W, Cheng T Microorganisms. 2023; 11(2).

PMID: 36838484 PMC: 9965970. DOI: 10.3390/microorganisms11020519.

Development of an Indirect ELISA Kit for Rapid Detection of Varicella-Zoster Virus Antibody by Glycoprotein E.

Niu Y, Wang A, Zhou J, Liu H, Chen Y, Ding P Front Microbiol. 2022; 13:897752.

PMID: 35572642 PMC: 9093680. DOI: 10.3389/fmicb.2022.897752.

Live Attenuated Varicella Vaccine: Prevention of Varicella and of Zoster.

Gershon A, Gershon M, Shapiro E J Infect Dis. 2021; 224(12 Suppl 2):S387-S397.

PMID: 34590140 PMC: 8482020. DOI: 10.1093/infdis/jiaa573.

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