Decrease of the Lymphoproliferative Response to Varicella-zoster Virus Antigen in the Aged

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1981 Apr 1

PMID 6163722

Citations 42

Authors

R Berger

G Florent

M Just

Affiliations

Soon will be listed here.

Abstract

Humoral antibodies and specific cellular immune reactions (proliferative immune response in the lymphocyte transformation test) to varicella-zoster virus antigen were measured in children, young adults, and elderly people. In children and young adults, the humoral varicella-zoster-specific antibodies and the virus-specific cellular immune response generally coincided. In the over-60 age group, however, a discrepancy was often observed between these parameters. Ninety percent of the elderly subjects showed humoral antibodies, but only 64% still had a measurable varicella-zoster-specific immune response. There was no correlation between the magnitude of the virus antigen-specific immune response and the mitogen-induced lymphoproliferative response (phytohemagglutinin stimulation). One in three elderly people, therefore, showed no cellular immune response to the varicella-zoster virus antigen, and this person could probably be regarded as a potential herpes zoster patient.

Citing Articles

A Prognostic Model Incorporating Relevant Peripheral Blood Inflammation Indicator to Predict Postherpetic Neuralgia in Patients with Acute Herpes Zoster.

Cai M, Yin J, Zeng Y, Liu H, Jin Y J Pain Res. 2024; 17:2299-2309.

PMID: 38974827 PMC: 11225992. DOI: 10.2147/JPR.S466939.

Heterogeneity of memory T cells in aging.

Jain A, Sturmlechner I, Weyand C, Goronzy J Front Immunol. 2023; 14:1250916.

PMID: 37662959 PMC: 10471982. DOI: 10.3389/fimmu.2023.1250916.

T cell fate decisions during memory cell generation with aging.

Sturmlechner I, Jain A, Mu Y, Weyand C, Goronzy J Semin Immunol. 2023; 69:101800.

PMID: 37494738 PMC: 10528238. DOI: 10.1016/j.smim.2023.101800.

Comparative Antibody Responses to the Live-Attenuated and Recombinant Herpes Zoster Vaccines.

Schmid D, Miao C, Leung J, Johnson M, Weinberg A, Levin M J Virol. 2021; 95(12).

PMID: 33762414 PMC: 8316136. DOI: 10.1128/JVI.00240-21.

Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey.

ElTanbouly M, Noelle R Nat Rev Immunol. 2020; 21(4):257-267.

PMID: 33077935 DOI: 10.1038/s41577-020-00454-2.

References

Glasgow L . Cellular immunity in host resistance to viral infections. Arch Intern Med. 1970; 126(1):125-34. View

MILLER L, Brunell P . Zoster, reinfection or activation of latent virus? Observations on the antibody response. Am J Med. 1970; 49(4):480-3. DOI: 10.1016/s0002-9343(70)80042-0. View

Pellegrino M, Ferrone S, Pellegrino A, Reisfeld R . A rapid microtechnique for in vitro stimulation of human lymphocytes by phytohemagglutinin. Clin Immunol Immunopathol. 1973; 2(1):67-73. DOI: 10.1016/0090-1229(73)90037-8. View

Williams V, Gershon A, Brunell P . Serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence. J Infect Dis. 1974; 130(6):669-72. DOI: 10.1093/infdis/130.6.669. View

Graziano K, Ruckdeschel J, MARDINEY Jr M . Cell-associated immunity to measles (rubeola). The demonstration of in vitro lymphocyte tritiated thymidine incorporation in response to measels complement fixation antigen. Cell Immunol. 1975; 15(2):347-59. DOI: 10.1016/0008-8749(75)90013-1. View

Kay M, Makinodan T . Immunobiology of aging: evaluation of current status. Clin Immunol Immunopathol. 1976; 6(3):394-413. DOI: 10.1016/0090-1229(76)90093-3. View

Ruckdeschel J, MARDINEY Jr M . The demonstration of cell-associated immunity to viruses. In vitro lymphocyte responsiveness to Varicella-zoster antigen. J Immunol Methods. 1976; 13(2):131-43. DOI: 10.1016/0022-1759(76)90151-4. View

Chiba Y, Sadeghi E, Ogra P . Abnormalities of cellular immune response in arthritis induced by rubella vaccination. J Immunol. 1976; 117(5 Pt 1):1684-7. View

Weiner H, Scribner D, Schocket A, Moorhead J . Increased proliferative response of human peripheral blood lymphocytes to anti-immunoglobulin antibodies in elderly people. Clin Immunol Immunopathol. 1978; 9(3):356-62. DOI: 10.1016/0090-1229(78)90107-1. View

10.

Hayes F, Feldman S . Cell-mediated immunity to varicella zoster virus in children being treated for cancer. Cancer. 1978; 42(1):159-63. DOI: 10.1002/1097-0142(197807)42:1<159::aid-cncr2820420126>3.0.co;2-e. View

11.

Chiba Y, FitzPatrick P, Patel P, Scott R, Ogra P . Age related differences in cellular immune response to vaccine induced rubella infection. Microbiol Immunol. 1978; 22(6):325-34. DOI: 10.1111/j.1348-0421.1978.tb00377.x. View

12.

Jennings R, Fenton R, McENTEGART M, POTTER C . A contribution of cellular immunity to protection against influenza in man. Med Microbiol Immunol. 1978; 166(1-4):51-62. DOI: 10.1007/BF02121134. View

13.

Patel P, Yoonessi S, OMalley J, Freeman A, Gershon A, Ogra P . Cell-mediated immunity to varicella-zoster virus infection in subjects with lymphoma or leukemia. J Pediatr. 1979; 94(2):223-30. DOI: 10.1016/s0022-3476(79)80828-8. View

14.

Chow T, Beutner K, Ogra P . Cell-mediated immune responses to the hemagglutinin and neuraminidase antigens of influenza A virus after immunization in humans. Infect Immun. 1979; 25(1):103-9. PMC: 414427. DOI: 10.1128/iai.25.1.103-109.1979. View

15.

Preblud S, DAngelo L . Chickenpox in the United States, 1972--1977. J Infect Dis. 1979; 140(2):257-60. DOI: 10.1093/infdis/140.2.257. View

16.

Just M, BUERGIN-WOLFF A . Initial experience with varicella immunization. Monogr Paediatr. 1979; 11:54-7. View