Antimicrobial Susceptibilities of Health Care-associated and Community-associated Strains of Methicillin-resistant Staphylococcus Aureus from Hospitalized Patients in Canada, 1995 to 2008

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2010 Mar 17

PMID 20231402

Citations 6

Authors

Andrew E Simor

Lisa Louie

Christine Watt

Denise Gravel

Michael R Mulvey

Jennifer Campbell

Allison McGeer

Elizabeth Bryce

Mark Loeb

Anne Matlow

Affiliations

Soon will be listed here.

Abstract

We determined the in vitro antimicrobial susceptibilities of 7,942 methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from patients hospitalized in 48 Canadian hospitals from 1995 to 2008. Regional variations in susceptibilities were identified. The dissemination of community-associated strains in Canada appears to have contributed to increased susceptibility of MRSA to several non-beta-lactam antimicrobial agents in the past decade. Reduced susceptibility to glycopeptides was not identified.

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References

Louie L, Matsumura S, Choi E, Louie M, Simor A . Evaluation of three rapid methods for detection of methicillin resistance in Staphylococcus aureus. J Clin Microbiol. 2000; 38(6):2170-3. PMC: 86755. DOI: 10.1128/JCM.38.6.2170-2173.2000. View

Simor A, Gilbert N, Gravel D, Mulvey M, Bryce E, Loeb M . Methicillin-resistant Staphylococcus aureus colonization or infection in Canada: National Surveillance and Changing Epidemiology, 1995-2007. Infect Control Hosp Epidemiol. 2010; 31(4):348-56. DOI: 10.1086/651313. View

Mulvey M, Chui L, Ismail J, Louie L, Murphy C, Chang N . Development of a Canadian standardized protocol for subtyping methicillin-resistant Staphylococcus aureus using pulsed-field gel electrophoresis. J Clin Microbiol. 2001; 39(10):3481-5. PMC: 88375. DOI: 10.1128/JCM.39.10.3481-3485.2001. View

Oliveira D, de Lencastre H . Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2002; 46(7):2155-61. PMC: 127318. DOI: 10.1128/AAC.46.7.2155-2161.2002. View

Simor A, Ofner-Agostini M, Bryce E, McGeer A, Paton S, Mulvey M . Laboratory characterization of methicillin-resistant Staphylococcus aureus in Canadian hospitals: results of 5 years of National Surveillance, 1995-1999. J Infect Dis. 2002; 186(5):652-60. DOI: 10.1086/342292. View

Liu C, Chambers H . Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods. Antimicrob Agents Chemother. 2003; 47(10):3040-5. PMC: 201119. DOI: 10.1128/AAC.47.10.3040-3045.2003. View

Naimi T, LeDell K, Como-Sabetti K, Borchardt S, Boxrud D, Etienne J . Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003; 290(22):2976-84. DOI: 10.1001/jama.290.22.2976. View

Hiramatsu K, Aritaka N, Hanaki H, Kawasaki S, Hosoda Y, Hori S . Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet. 1997; 350(9092):1670-3. DOI: 10.1016/S0140-6736(97)07324-8. View

Deresinski S . Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey. Clin Infect Dis. 2005; 40(4):562-73. DOI: 10.1086/427701. View

10.

Howden B, Grayson M . Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus. Clin Infect Dis. 2006; 42(3):394-400. DOI: 10.1086/499365. View

11.

Gilbert M, MacDonald J, Gregson D, Siushansian J, Zhang K, Elsayed S . Outbreak in Alberta of community-acquired (USA300) methicillin-resistant Staphylococcus aureus in people with a history of drug use, homelessness or incarceration. CMAJ. 2006; 175(2):149-54. PMC: 1490001. DOI: 10.1503/cmaj.051565. View

12.

Howden B, Johnson P, Ward P, Stinear T, Davies J . Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2006; 50(9):3039-47. PMC: 1563555. DOI: 10.1128/AAC.00422-06. View

13.

Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E . Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet. 2006; 368(9538):874-85. DOI: 10.1016/S0140-6736(06)68853-3. View

14.

Wang G, Hindler J, Ward K, Bruckner D . Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period. J Clin Microbiol. 2006; 44(11):3883-6. PMC: 1698298. DOI: 10.1128/JCM.01388-06. View

15.

Webster D, Rennie R, Brosnikoff C, Chui L, Brown C . Methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Canada. Diagn Microbiol Infect Dis. 2006; 57(2):177-81. DOI: 10.1016/j.diagmicrobio.2006.07.007. View

16.

Christianson S, Golding G, Campbell J, Mulvey M . Comparative genomics of Canadian epidemic lineages of methicillin-resistant Staphylococcus aureus. J Clin Microbiol. 2007; 45(6):1904-11. PMC: 1933033. DOI: 10.1128/JCM.02500-06. View

17.

Simor A, Stuart T, Louie L, Watt C, Ofner-Agostini M, Gravel D . Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrob Agents Chemother. 2007; 51(11):3880-6. PMC: 2151460. DOI: 10.1128/AAC.00846-07. View

18.

Popovich K, Weinstein R, Hota B . Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?. Clin Infect Dis. 2008; 46(6):787-94. DOI: 10.1086/528716. View

19.

Liu C, Graber C, Karr M, Diep B, Basuino L, Schwartz B . A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008; 46(11):1637-46. DOI: 10.1086/587893. View

20.

Horan T, Andrus M, Dudeck M . CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008; 36(5):309-32. DOI: 10.1016/j.ajic.2008.03.002. View