Circadian Clock Control of the Cellular Response to DNA Damage

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2010 Mar 16

PMID 20227409

Citations 125

Authors

Aziz Sancar

Laura A Lindsey-Boltz

Tae-Hong Kang

Joyce T Reardon

Jin Hyup Lee

Nuri Ozturk

Affiliations

Soon will be listed here.

Abstract

Mammalian cells possess a cell-autonomous molecular clock which controls the timing of many biochemical reactions and hence the cellular response to environmental stimuli including genotoxic stress. The clock consists of an autoregulatory transcription-translation feedback loop made up of four genes/proteins, BMal1, Clock, Cryptochrome, and Period. The circadian clock has an intrinsic period of about 24 h, and it dictates the rates of many biochemical reactions as a function of the time of the day. Recently, it has become apparent that the circadian clock plays an important role in determining the strengths of cellular responses to DNA damage including repair, checkpoints, and apoptosis. These new insights are expected to guide development of novel mechanism-based chemotherapeutic regimens.

Citing Articles

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