INKT Cell Autoreactivity: What is 'self' and How is It Recognized?

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Mar 13

PMID 20224567

Citations 49

Authors

Laurent Gapin

Affiliations

Soon will be listed here.

Abstract

Following stimulation through their T cell receptor, invariant natural killer T (iNKT) cells function as innate effector cells by rapidly releasing large amounts of effector cytokines and chemokines and therefore have an important role in modulating the ensuing immune response. iNKT cells recognize, and are activated by, diverse glycolipid antigens, many of which are found in microorganisms. However, iNKT cells also show some reactivity to 'self'. Here, I outline our current understanding of iNKT cell autoreactivity and propose that several self lipids are probably involved in the positive selection and autoreactivity of iNKT cells.

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