MYBBP1A: a New Ipr1's Binding Protein in Mice

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2010 Mar 12

PMID 20221700

Citations 8

Authors

Lei Cai

Hui Pan

Krzysztof Trzcinski

Claudette M Thompson

Qiang Wu

Igor Kramnik

Affiliations

Soon will be listed here.

Abstract

Infection with mycobacterium tuberculosis (MTB) can cause different outcomes in hosts with variant genetic backgrounds. Previously, we identified an intracellular pathogen resistance 1 (Ipr1) gene with the role of resistance of MTB infection in mice model. However, until now, its binding proteins have been little known even for its human homology, SP110. In this study, the homology for mouse Ipr1 in canines was found to have an extra domain structure, h.1.5.1. And 30 potential candidate proteins were predicted to bind canine Ipr1, which were characterized of the interacting structure with the h.1.5.1. Among them, MYBBP1A was verified to bind with both Ipr1 and eGFP-Ipr1 in mouse macrophage J774A.1 clone 21 cells using co-immunoprecipitation method. And with the constructed high-confidence Ipr1-involved network, we suggested that Ipr1 might be involved in apoptosis pathway via MYBBP1A.

Citing Articles

Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia.

Cai L, Huang T, Su J, Zhang X, Chen W, Zhang F Mol Ther Nucleic Acids. 2018; 12:433-442.

PMID: 30195780 PMC: 6041437. DOI: 10.1016/j.omtn.2018.05.026.

Sp110 enhances macrophage resistance to via inducing endoplasmic reticulum stress and inhibiting anti-apoptotic factors.

Wu Y, Guo Z, Liu F, Yao K, Gao M, Luo Y Oncotarget. 2017; 8(38):64050-64065.

PMID: 28969051 PMC: 5609983. DOI: 10.18632/oncotarget.19300.

The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1.

Yao K, Wu Y, Chen Q, Zhang Z, Chen X, Zhang Y PLoS One. 2016; 11(9):e0162832.

PMID: 27622275 PMC: 5021326. DOI: 10.1371/journal.pone.0162832.

The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra.

Wu Y, Guo Z, Yao K, Miao Y, Liang S, Liu F Sci Rep. 2016; 6:22041.

PMID: 26912204 PMC: 4766572. DOI: 10.1038/srep22041.

Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1.

Wu Y, Liu F, Zhang Y, Wang Y, Guo Z, Zhang Y Immunol Res. 2015; 64(1):143-54.

PMID: 26590945 DOI: 10.1007/s12026-015-8732-3.

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