Igor Kramnik
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Explore the profile of Igor Kramnik including associated specialties, affiliations and a list of published articles.
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51
Citations
1926
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Recent Articles
1.
Lata S, Yabaji S, OConnell A, Gertje H, Kirber M, Crossland N, et al.
STAR Protoc
. 2025 Feb;
6(1):103640.
PMID: 39982826
To detect multiple protein markers, here we present a protocol for imaging pulmonary tuberculosis (PTB) lesions from murine lungs using Opal-tyramide signal amplification (TSA) conjugated fluorescent dyes in free-floating formalin-fixed...
2.
Koyuncu D, Tavolara T, Gatti D, Gower A, Ginese M, Kramnik I, et al.
Infect Immun
. 2024 Jun;
92(7):e0026323.
PMID: 38899881
Because most humans resist infection, there is a paucity of lung samples to study. To address this gap, we infected Diversity Outbred mice with and studied the lungs of mice...
3.
Gatti D, Tyler A, Mahoney J, Churchill G, Yener B, Koyuncu D, et al.
PLoS Pathog
. 2024 Jun;
20(6):e1011915.
PMID: 38861581
Mycobacterium tuberculosis infects two billion people across the globe, and results in 8-9 million new tuberculosis (TB) cases and 1-1.5 million deaths each year. Most patients have no known genetic...
4.
Dartois V, Bonfield T, Boyce J, Daley C, Dick T, Gonzalez-Juarrero M, et al.
Tuberculosis (Edinb)
. 2024 May;
147:102503.
PMID: 38729070
Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, is increasingly recognized as an important pathogen of the human lung, disproportionally affecting people with cystic fibrosis (CF) and other susceptible individuals with...
5.
Yabaji S, Zhernovkov V, Araveti P, Lata S, Rukhlenko O, Al Abdullatif S, et al.
bioRxiv
. 2024 Mar;
PMID: 38496444
A quarter of human population is infected with Mycobacterium tuberculosis, but less than 10% of those infected develop pulmonary TB. We developed a genetically defined sst1-susceptible mouse model that uniquely...
6.
Amaral E, Namasivayam S, Queiroz A, Fukutani E, Hilligan K, Aberman K, et al.
Nat Microbiol
. 2023 Dec;
9(1):120-135.
PMID: 38066332
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor...
7.
Yabaji S, Rukhlenko O, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, et al.
Sci Adv
. 2023 Sep;
9(39):eadh4119.
PMID: 37756395
Understanding cell state transitions and purposefully controlling them to improve therapies is a longstanding challenge in biological research and medicine. Here, we identify a transcriptional signature that distinguishes activated macrophages...
8.
Klever A, Alexander K, Almeida D, Anderson M, Ball R, Beamer G, et al.
Tuberculosis (Edinb)
. 2023 Aug;
142:102377.
PMID: 37531864
The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge of numerous mycobacterial...
9.
Krug S, Prasad P, Xiao S, Lun S, Ruiz-Bedoya C, Klunk M, et al.
mBio
. 2023 Feb;
14(2):e0349622.
PMID: 36853048
Despite numerous advances in tuberculosis (TB) drug development, long treatment durations have led to the emergence of multidrug resistance, which poses a major hurdle to global TB control. Shortening treatment...
10.
Yabaji S, Rukhlenko O, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798271
Understanding cell state transitions and purposefully controlling them to improve therapies is a longstanding challenge in biological research and medicine. Here, we identify a transcriptional signature that distinguishes activated macrophages...