On the Origin of MADS-domain Transcription Factors

Overview

Journal Trends Genet

Specialty Genetics

Date 2010 Mar 12

PMID 20219261

Citations 60

Authors

Lydia Gramzow

Markus S Ritz

Gunter Theissen

Affiliations

Soon will be listed here.

Abstract

MADS-domain transcription factors are involved in signal transduction and developmental control in plants, animals and fungi. Because their diversification is linked to the origin of novelties in multicellular eukaryotes, the early evolution of MADS-domain proteins is of interest, but has remained enigmatic. Employing whole genome sequence information and remote homology detection methods, we demonstrate that the MADS domain originated from a region of topoisomerases IIA subunit A. Furthermore, we provide evidence that gene duplication occurred in the lineage that led to the MRCA of extant eukaryotes, giving rise to SRF-like and MEF2-like MADS-box genes.

Citing Articles

Genome-Wide Investigation of Genes in Flower Development and Environmental Acclimation of (Jack) Voigt.

Zhang L, Yang Y, Zhang Y, Yang F Int J Mol Sci. 2025; 26(4).

PMID: 40004145 PMC: 11855919. DOI: 10.3390/ijms26041680.

The dynamic regulatory network of stamens and pistils in papaya.

Xiang T, Zhu Y, Wang Y, Chen X, Zhang Z, Lai J BMC Plant Biol. 2025; 25(1):254.

PMID: 39994552 PMC: 11853724. DOI: 10.1186/s12870-025-06242-1.

Multiple combinatorial interactions among natural structural variants of Brassica SOC1 promoters and SVP: conservation of binding affinity despite diversity in bimolecular interactions.

Kaur S, Sisodia R, Gupta B, Gaikwad K, Madhurantakam C, Singh A Mol Biol Rep. 2025; 52(1):187.

PMID: 39899150 DOI: 10.1007/s11033-024-10182-8.

Asymmetry of Motif Conservation Within Their Homotypic Pairs Distinguishes DNA-Binding Domains of Target Transcription Factors in ChIP-Seq Data.

Levitsky V, Raditsa V, Tsukanov A, Mukhin A, Zhimulev I, Merkulova T Int J Mol Sci. 2025; 26(1.

PMID: 39796242 PMC: 11720554. DOI: 10.3390/ijms26010386.

Characterization of MADS-Box Gene Family in and Functional Study of in Regulating Floral Transition and Formation.

Ma Y, Lan Y, Li J, Long H, Zhou Y, Li Z Plants (Basel). 2025; 14(1.

PMID: 39795389 PMC: 11723362. DOI: 10.3390/plants14010129.