Uncovering Gene-family Founder Events During Major Evolutionary Transitions in Animals, Plants and Fungi Using GenEra

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2023 Mar 25

PMID 36964572

Authors

Josue Barrera-Redondo

Jaruwatana Sodai Lotharukpong

Hajk-Georg Drost

Susana M Coelho

Affiliations

Soon will be listed here.

Abstract

We present GenEra ( https://github.com/josuebarrera/GenEra ), a DIAMOND-fueled gene-family founder inference framework that addresses previously raised limitations and biases in genomic phylostratigraphy, such as homology detection failure. GenEra also reduces computational time from several months to a few days for any genome of interest. We analyze the emergence of taxonomically restricted gene families during major evolutionary transitions in plants, animals, and fungi. Our results indicate that the impact of homology detection failure on inferred patterns of gene emergence is lineage-dependent, suggesting that plants are more prone to evolve novelty through the emergence of new genes compared to animals and fungi.

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